Effects of methadone use during pregnancy on human placental opioid receptors

Mahmoud S. Ahmed, Bojana Cemerikic, Susan Mou, Abdulbaki Agbas

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Human placenta was used to investigate the effects of chronic methadone use during pregnancy on villus tissue opioid receptors. Patients included in this investigation received 35-60 mg methadone per day. Methadone-exposed placenta villus tissue had no detectable opioid receptor binding sites measured by tritiated opioid agonists. In vitro release of acetylcholine and hCG from trophoblast tissue of methadone-exposed placentas was not modulated by opioids. Absence of opioid receptor binding sites and their two mediated responses in trophoblast tissue of placentas obtained from patients with documented chronic methadone use during pregnancy indicate that the receptors were down regulated or desensitized.

Original languageEnglish (US)
Pages (from-to)91-98
Number of pages8
JournalMolecular membrane biology
Volume10
Issue number2
DOIs
StatePublished - Jan 1 1993
Externally publishedYes

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Keywords

  • Drug use
  • Opioid receptors
  • Pregnancy

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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