Effects of microamperage, medium, and bacterial concentration on iontophoretic killing of bacteria in fluid

C. P. Davis, S. Weinberg, M. D. Anderson, G. M. Rao, M. M. Warren

    Research output: Contribution to journalArticle

    30 Scopus citations

    Abstract

    Prevention of nosocomial urinary tract infections by iontophoresis is addressed. An iontophoretic generator was used to provide microamperage (10 to 400 μA) to vials containing either synthetic urine or supplemented synthetic urine. Bacteria were added to vials, and parameters of growth, bacterial killing, and multiple electrode materials were examined. Escherichia coli and Proteus species were both inhibited and killed at various microamperages and with several electrode types, the most efficient being gold-gold as the anodecathode combination. Klebsiella pneumoniae in supplemented synthetic urine was least inhibited in growth, and higher microamperage (200 to 400 μA) was most effective in killing the bacteria. Bacterial growth reduction and killing were directly related to increasing microamperage and were inversely related to bacterial concentration.

    Original languageEnglish (US)
    Pages (from-to)442-447
    Number of pages6
    JournalAntimicrobial agents and chemotherapy
    Volume33
    Issue number4
    DOIs
    StatePublished - 1989

    ASJC Scopus subject areas

    • Pharmacology
    • Pharmacology (medical)
    • Infectious Diseases

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