Effects of microamperage, medium, and bacterial concentration on iontophoretic killing of bacteria in fluid

C. P. Davis, S. Weinberg, M. D. Anderson, G. M. Rao, M. M. Warren

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Prevention of nosocomial urinary tract infections by iontophoresis is addressed. An iontophoretic generator was used to provide microamperage (10 to 400 μA) to vials containing either synthetic urine or supplemented synthetic urine. Bacteria were added to vials, and parameters of growth, bacterial killing, and multiple electrode materials were examined. Escherichia coli and Proteus species were both inhibited and killed at various microamperages and with several electrode types, the most efficient being gold-gold as the anodecathode combination. Klebsiella pneumoniae in supplemented synthetic urine was least inhibited in growth, and higher microamperage (200 to 400 μA) was most effective in killing the bacteria. Bacterial growth reduction and killing were directly related to increasing microamperage and were inversely related to bacterial concentration.

Original languageEnglish (US)
Pages (from-to)442-447
Number of pages6
JournalAntimicrobial agents and chemotherapy
Volume33
Issue number4
DOIs
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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