Effects of nerve growth factor and its antibodies on sprouting of sensory axons following spinal cord hemisection

C. E. Hulsebosch, R. E. Coggeshall, J. R. Perez-Polo

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    Axons were counted in rat dorsal roots three segments cranial and three segments caudal to a spinal hemisection done at birth. The animals were placed in three groups: (1) hemisected (HEMI), (2) hemisected and given nerve growth factor (NGF) daily (HEMI + NGF) and (3) hemisected and given antibodies to NGF daily (HEMI + anti-NGF). They were sacrificed at 1 month. In the HEMI and HEMI + NGF groups, there were 20% and 13% more unmyelinated axons, respectively, in roots of the operated side. We interpret these differences to be the result of sprouting of unmyelinated axons as a result of denervation, and exogenous NGF does not seem to affect the response. By contrast, the unmyelinated axon responses in HEMI + anti-NGF animals are different. These animals have approximately 7% more unmyelinated axons on the denervated side and 50% more axons on the normal side than in the other animals we studied. The results on the anti-NGF animals are interpreted as indicating sprouting in response to a chemical denervation caused by NGF removal and the response is more dramatic on the unoperated side.

    Original languageEnglish (US)
    Pages (from-to)1-10
    Number of pages10
    JournalBrain Research
    Volume323
    Issue number1
    DOIs
    StatePublished - Dec 3 1984

    Fingerprint

    Nerve Growth Factor
    Axons
    Spinal Cord
    Antibodies
    Denervation
    Spinal Nerve Roots
    Parturition

    Keywords

    • anti-nerve growth factor
    • axonal sprouting
    • nerve growth factor
    • unmyelinated axons

    ASJC Scopus subject areas

    • Developmental Biology
    • Molecular Biology
    • Clinical Neurology
    • Neuroscience(all)

    Cite this

    Effects of nerve growth factor and its antibodies on sprouting of sensory axons following spinal cord hemisection. / Hulsebosch, C. E.; Coggeshall, R. E.; Perez-Polo, J. R.

    In: Brain Research, Vol. 323, No. 1, 03.12.1984, p. 1-10.

    Research output: Contribution to journalArticle

    Hulsebosch, C. E. ; Coggeshall, R. E. ; Perez-Polo, J. R. / Effects of nerve growth factor and its antibodies on sprouting of sensory axons following spinal cord hemisection. In: Brain Research. 1984 ; Vol. 323, No. 1. pp. 1-10.
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