Effects of nitric oxide synthase inhibition on the hemodynamic changes in hyperdynamic endotoxemia.

A. Wolfárd, J. Kaszaki, C. Szabó, Z. Balogh, S. Nagy

    Research output: Contribution to journalArticle

    2 Scopus citations

    Abstract

    In this study we compared the circulatory effects of the arginine analogue non-specific nitric oxide synthase (NOS) inhibitor N omega-nitro-L-arginine (NNA), and the specific inducible NOS (iNOS) inhibitor S-methylisothiourea (SMT) and S-(2-aminoethyl)-isothiourea (AEST) in a hyperdynamic endotoxemic dog model. Mean arterial pressure (MAP), cardiac output (CO), and myocardial contractility (MC) were measured. A hyperdynamic circulatory response was elicited with a 2-h infusion of a total dose of 5.3 micrograms/kg E. coli endotoxin (ETX). NOS inhibitory treatment (2 mg/kg) was administrated from the 45th min of endotoxemia. ETX induced a hyperdynamic circulatory response, and a significant myocardial depression. NNA induced a prolonged, SMT a transient increase in MC, both drugs elevated MAP, but decreased CO. AEST significantly prolonged the elevation in CO, but did not affect MAP. Selective inhibition of the iNOS may be a beneficial in sepsis.

    Original languageEnglish (US)
    Pages (from-to)393-394
    Number of pages2
    JournalActa chirurgica Hungarica
    Volume36
    Issue number1-4
    StatePublished - 1997

    ASJC Scopus subject areas

    • Surgery

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    Wolfárd, A., Kaszaki, J., Szabó, C., Balogh, Z., & Nagy, S. (1997). Effects of nitric oxide synthase inhibition on the hemodynamic changes in hyperdynamic endotoxemia. Acta chirurgica Hungarica, 36(1-4), 393-394.