Effects of nitric oxide synthase inhibition on the hemodynamic changes in hyperdynamic endotoxemia.

A. Wolfárd, J. Kaszaki, Csaba Szabo, Z. Balogh, S. Nagy

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In this study we compared the circulatory effects of the arginine analogue non-specific nitric oxide synthase (NOS) inhibitor N omega-nitro-L-arginine (NNA), and the specific inducible NOS (iNOS) inhibitor S-methylisothiourea (SMT) and S-(2-aminoethyl)-isothiourea (AEST) in a hyperdynamic endotoxemic dog model. Mean arterial pressure (MAP), cardiac output (CO), and myocardial contractility (MC) were measured. A hyperdynamic circulatory response was elicited with a 2-h infusion of a total dose of 5.3 micrograms/kg E. coli endotoxin (ETX). NOS inhibitory treatment (2 mg/kg) was administrated from the 45th min of endotoxemia. ETX induced a hyperdynamic circulatory response, and a significant myocardial depression. NNA induced a prolonged, SMT a transient increase in MC, both drugs elevated MAP, but decreased CO. AEST significantly prolonged the elevation in CO, but did not affect MAP. Selective inhibition of the iNOS may be a beneficial in sepsis.

Original languageEnglish (US)
Pages (from-to)393-394
Number of pages2
JournalActa Chirurgica Hungarica
Volume36
Issue number1-4
StatePublished - 1997
Externally publishedYes

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Endotoxemia
beta-Aminoethyl Isothiourea
Nitric Oxide Synthase
Cardiac Output
Arterial Pressure
Nitroarginine
Hemodynamics
Endotoxins
Nitric Oxide Synthase Type II
Arginine
Sepsis
Dogs
Escherichia coli
Pharmaceutical Preparations
S-methylisothiopseudouronium

ASJC Scopus subject areas

  • Surgery

Cite this

Effects of nitric oxide synthase inhibition on the hemodynamic changes in hyperdynamic endotoxemia. / Wolfárd, A.; Kaszaki, J.; Szabo, Csaba; Balogh, Z.; Nagy, S.

In: Acta Chirurgica Hungarica, Vol. 36, No. 1-4, 1997, p. 393-394.

Research output: Contribution to journalArticle

Wolfárd, A. ; Kaszaki, J. ; Szabo, Csaba ; Balogh, Z. ; Nagy, S. / Effects of nitric oxide synthase inhibition on the hemodynamic changes in hyperdynamic endotoxemia. In: Acta Chirurgica Hungarica. 1997 ; Vol. 36, No. 1-4. pp. 393-394.
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