Effects of nitrogen dioxide exposure on human host defense

Mitra Azadniv, Mark J. Utell, Paul E. Morrow, F. Raymond Gibb, Joan Nichols, Norbert J. Roberts, Donna M. Speers, Alfonso Torres, Ying Tsai, Michael K. Abraham, Karen Z. Voter, Mark W. Frampton

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Nitrogen dioxide (NO2) exposure has been linked with increased respiratory illness and infection. The objective of this study was to determine whether exposure at peak indoor levels causes airway inflammation or impairs local or systemic host defense in humans either immediately or 18 h after exposure. In an initial phase, 12 volunteers were exposed to purified air or a targeted concentration of 2.0 ppm NO2 for 6 h, with intermittent exercise, and underwent bronchoalveolar lavage (BAL) 18 h after exposure. In a second phase, 12 volunteers participated in an identical exposure protocol but BAL was performed immediately after exposure. Eighteen hours after exposure to NO2, polymorphonuclear leukocytes recovered by BAL increased from 2.2 ± 0.3 to 3.1 ± 0.4% (p = .005) and small decreases were found in the percentage of blood CD8+ T lymphocytes (p = .01) and in blood T lymphocytes expressing neither CD4 nor CD8 (p = .03). These variables were not significantly different immediately after NO2 exposure. Nitrogen dioxide exposure did not alter lymphocyte subsets in BAL or alveolar macrophage function at either time point. Exposure to 2.0 ppm NO2 for 6 h with exercise causes airway inflammation and may alter blood lymphocyte populations 18 h after exposure.

Original languageEnglish (US)
Pages (from-to)585-601
Number of pages17
JournalInhalation Toxicology
Volume10
Issue number6
StatePublished - Jun 1998

Fingerprint

Nitrogen Dioxide
Bronchoalveolar Lavage
Blood
T-cells
Lymphocytes
Volunteers
Exercise
Inflammation
Set theory
T-Lymphocytes
Lymphocyte Subsets
Alveolar Macrophages
Respiratory Tract Infections
Neutrophils
Air
Population

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Azadniv, M., Utell, M. J., Morrow, P. E., Gibb, F. R., Nichols, J., Roberts, N. J., ... Frampton, M. W. (1998). Effects of nitrogen dioxide exposure on human host defense. Inhalation Toxicology, 10(6), 585-601.

Effects of nitrogen dioxide exposure on human host defense. / Azadniv, Mitra; Utell, Mark J.; Morrow, Paul E.; Gibb, F. Raymond; Nichols, Joan; Roberts, Norbert J.; Speers, Donna M.; Torres, Alfonso; Tsai, Ying; Abraham, Michael K.; Voter, Karen Z.; Frampton, Mark W.

In: Inhalation Toxicology, Vol. 10, No. 6, 06.1998, p. 585-601.

Research output: Contribution to journalArticle

Azadniv, M, Utell, MJ, Morrow, PE, Gibb, FR, Nichols, J, Roberts, NJ, Speers, DM, Torres, A, Tsai, Y, Abraham, MK, Voter, KZ & Frampton, MW 1998, 'Effects of nitrogen dioxide exposure on human host defense', Inhalation Toxicology, vol. 10, no. 6, pp. 585-601.
Azadniv M, Utell MJ, Morrow PE, Gibb FR, Nichols J, Roberts NJ et al. Effects of nitrogen dioxide exposure on human host defense. Inhalation Toxicology. 1998 Jun;10(6):585-601.
Azadniv, Mitra ; Utell, Mark J. ; Morrow, Paul E. ; Gibb, F. Raymond ; Nichols, Joan ; Roberts, Norbert J. ; Speers, Donna M. ; Torres, Alfonso ; Tsai, Ying ; Abraham, Michael K. ; Voter, Karen Z. ; Frampton, Mark W. / Effects of nitrogen dioxide exposure on human host defense. In: Inhalation Toxicology. 1998 ; Vol. 10, No. 6. pp. 585-601.
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