Effects of oral laxatives on colonic motor complexes in dogs

M. Karaus, S. K. Sarna, H. V. Ammon, M. Wienbeck

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The effect of oral laxatives on the organisation of colonic motor complexes was investigated in four conscious dogs. Six strain gauge transducers were implanted on the colon of each dog. After a control period of two to three hours, dogs were orally dosed with 1, 2, or 4 ml/kg of castor oil, or 0*5 g/kg magnesium citrate. Oral olive oil, 4 ml/kg, was used as control. The recording was continued for another 10 hours or until defecation occurred. Each dog showed spontaneous cyclic bursts of contractions (contractile states) at all recording sites during the control period. Contractile states migrating orad or caudad over at least half the length of the colon were called colonic migrating motor complexes (CMMC). Castor oil and magnesium citrate significantly increased the period of colonic motor complexes, but olive oil had no significant effect. None of the above substances changed the percentage of orad migrating motor complexes, as compared with the control values. Periods in which colonic motor activity was completely absent for at least 60 min over at least three consecutive recording sites occurred more frequently after all of the substances. The occurrence of these periods of inhibition, however, was not a consistent feature and there seemed to be no relationship between the occurrence of inhibitory periods and defecation during the recording period. The dogs defecated within 10 hours after administration of magnesium citrate, 1, 2, and 4 ml/kg of castor oil in 12-5, 25, 37-5, and 88-8% of experiments respectively, but never with olive oil. Defecation was generally accompanied by giant migrating contractions in the colon. We conclude that oral laxatives, magnesium citrate and castor oil have a profound effect on colonic motor complexes and colonic motor activity. The period of CMMC is significantly prolonged after their oral administration because of an increased number of non-migrating motor complexes or periods of inhibition of motor activity.

Original languageEnglish (US)
Pages (from-to)1112-1119
Number of pages8
JournalGut
Volume28
Issue number9
DOIs
StatePublished - 1987
Externally publishedYes

Fingerprint

Laxatives
Castor Oil
Migrating Myoelectric Complexes
Defecation
Dogs
Colon
Motor Activity
Transducers
Oral Administration
magnesium citrate
Olive Oil

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Gastroenterology

Cite this

Karaus, M., Sarna, S. K., Ammon, H. V., & Wienbeck, M. (1987). Effects of oral laxatives on colonic motor complexes in dogs. Gut, 28(9), 1112-1119. https://doi.org/10.1136/gut.28.9.1112

Effects of oral laxatives on colonic motor complexes in dogs. / Karaus, M.; Sarna, S. K.; Ammon, H. V.; Wienbeck, M.

In: Gut, Vol. 28, No. 9, 1987, p. 1112-1119.

Research output: Contribution to journalArticle

Karaus, M, Sarna, SK, Ammon, HV & Wienbeck, M 1987, 'Effects of oral laxatives on colonic motor complexes in dogs', Gut, vol. 28, no. 9, pp. 1112-1119. https://doi.org/10.1136/gut.28.9.1112
Karaus M, Sarna SK, Ammon HV, Wienbeck M. Effects of oral laxatives on colonic motor complexes in dogs. Gut. 1987;28(9):1112-1119. https://doi.org/10.1136/gut.28.9.1112
Karaus, M. ; Sarna, S. K. ; Ammon, H. V. ; Wienbeck, M. / Effects of oral laxatives on colonic motor complexes in dogs. In: Gut. 1987 ; Vol. 28, No. 9. pp. 1112-1119.
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