Effects of oxandrolone on outcome measures in the severely burned: A multicenter prospective randomized double-blind trial

Steven Wolf, Linda S. Edelman, Nathan Kemalyan, Lorraine Donison, James Cross, Marcia Underwood, Robert J. Spence, Dene Noppenberger, Tina L. Palmieri, David G. Greenhalgh, Marybeth Lawless, David Voigt, Paul Edwards, Petra Warner, Richard Kagan, Susan Hatfield, James Jeng, Daria Crean, John Hunt, Gary PurdueAgnes Burris, Bruce Cairns, Mary Kessler, Robert L. Klein, Rose Baker, Charles Yowler, Wendy Tutulo, Kevin Foster, Daniel Caruso, Brian Hildebrand, Wesley Benjamin, Cynthia Villarreal, Arthur P. Sanford, Jeffrey Saffle

Research output: Contribution to journalArticle

104 Scopus citations

Abstract

Severe burns induce pathophysiologic problems, among them catabolism of lean mass, leading to protracted hospitalization and prolonged recovery. Oxandrolone is an anabolic agent shown to decrease lean mass catabolism and improve wound healing in the severely burned patients. We enrolled 81 adult subjects with burns 20% to 60% TBSA in a multicenter trial testing the effects of oxandrolone on length of hospital stay. Subjects were randomized between oxandrolone 10 mg every 12 hours or placebo. The study was stopped halfway through projected enrollment because of a significant difference between groups found on planned interim analysis. We found that length of stay was shorter in the oxandrolone group (31.6 ± 3.1 days) than placebo (43.3 ± 5.3 days; P < .05). This difference strengthened when deaths were excluded and hospital stay was indexed to burn size (1.24 ± 0.15 days/% TBSA burned vs 0.87 ± 0.05 days/% TBSA burned, P < .05). We conclude that treatment using oxandrolone should be considered for use in the severely burned while hepatic transaminases are monitored.

Original languageEnglish (US)
Pages (from-to)131-139
Number of pages9
JournalJournal of Burn Care and Research
Volume27
Issue number2
DOIs
StatePublished - Mar 1 2006
Externally publishedYes

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ASJC Scopus subject areas

  • Surgery
  • Emergency Medicine
  • Rehabilitation

Cite this

Wolf, S., Edelman, L. S., Kemalyan, N., Donison, L., Cross, J., Underwood, M., Spence, R. J., Noppenberger, D., Palmieri, T. L., Greenhalgh, D. G., Lawless, M., Voigt, D., Edwards, P., Warner, P., Kagan, R., Hatfield, S., Jeng, J., Crean, D., Hunt, J., ... Saffle, J. (2006). Effects of oxandrolone on outcome measures in the severely burned: A multicenter prospective randomized double-blind trial. Journal of Burn Care and Research, 27(2), 131-139. https://doi.org/10.1097/01.BCR.0000202620.55751.4F