Effects of partial left ventriculectomy on left ventricular geometry and wall stress in excised porcine hearts

G. Randall Green, Marc R. Moon, Abelardo DeAnda, George T. Daughters, Julie R. Glasson, D. Craig Miller

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background and aims of the study: Partial left ventriculectomy (PLV, the 'Batista procedure') has received recent attention as a surgical treatment for patients with dilated cardiomyopathy and end-stage congestive heart failure; however, the mechanisms responsible for the purported short-term improvement in left ventricular (LV) function are poorly characterized. This study examined the effects of PLV on three-dimensional (3-D) LV geometry, wall stress and passive LV mechanics in excised porcine hearts. Methods: Thirty-three radio-opaque tantalum markers were placed into the LV wall of nine freshly excised, porcine hearts (arrested with cold crystalloid cardioplegia) to measure three dimensional LV geometry and volume. Simultaneous biplane video-fluoroscopic marker images and LV pressure (LVP) were obtained over a wide range of LV volumes generated with an intracavitary LV balloon. Measurements were repeated after excision of a diamond-shaped wedge of the lateral LV wall between the papillary muscles (mean: 8 x 3 x 2 cm; 10 ± 2% of LV mass). Results: Following PLV, the ventricle assumed a more elliptical shape (LV eccentricity rose from 0.71 ± 0.15 to 0.81 ± 0.09, p2 (p

Original languageEnglish (US)
Pages (from-to)474-483
Number of pages10
JournalJournal of Heart Valve Disease
Volume7
Issue number5
StatePublished - Sep 1998
Externally publishedYes

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Swine
Tantalum
Induced Heart Arrest
Diamond
Papillary Muscles
Dilated Cardiomyopathy
Ventricular Pressure
Mechanics
Left Ventricular Function
Heart Failure
Therapeutics
crystalloid solutions
Radio-Opaque acrylic resin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Green, G. R., Moon, M. R., DeAnda, A., Daughters, G. T., Glasson, J. R., & Miller, D. C. (1998). Effects of partial left ventriculectomy on left ventricular geometry and wall stress in excised porcine hearts. Journal of Heart Valve Disease, 7(5), 474-483.

Effects of partial left ventriculectomy on left ventricular geometry and wall stress in excised porcine hearts. / Green, G. Randall; Moon, Marc R.; DeAnda, Abelardo; Daughters, George T.; Glasson, Julie R.; Miller, D. Craig.

In: Journal of Heart Valve Disease, Vol. 7, No. 5, 09.1998, p. 474-483.

Research output: Contribution to journalArticle

Green, G. Randall ; Moon, Marc R. ; DeAnda, Abelardo ; Daughters, George T. ; Glasson, Julie R. ; Miller, D. Craig. / Effects of partial left ventriculectomy on left ventricular geometry and wall stress in excised porcine hearts. In: Journal of Heart Valve Disease. 1998 ; Vol. 7, No. 5. pp. 474-483.
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