Effects of peptide YY on the growth of the pancreas and intestine

Difu Guan, Nathalie Rivard, Jean Morisset, George H. Greeley

    Research output: Contribution to journalArticle

    15 Citations (Scopus)

    Abstract

    The effects of Peptide YY (PYY) on pancreatic and intestinal growth have been investigated in conscious rats. Male Wistar rats equipped with jugular vein cannulas were randomly assigned to five groups. All rats received continuous iv infusion of gut peptides for 4 days, rats were then killed, and the pancreas and intestine were analyzed. Infusion of PYY alone at the dose of 400 pmol/kg · h affected neither pancreatic weight, DNA and RNA contents, or the duodenal weight, protein, DNA and RNA contents. Infusion of caerulein at the dose of 0.25 μg/kg · h significantly increased pancreatic weight, DNA, RNA, and protein contents by 202%, 109%, 171%, 183% above control values, but it did not affect duodenal weight, DNA, RNA, and protein contents. PYY, 400 pmol/kg · h, infused simultaneously with caerulein significantly reduced by 39%, 35%, and 45% increases in pancreatic weight, RNA and DNA contents stimulated by caerulein, respectively. Surprisingly, administration of PYY antiserum also resulted in a small but significant reduction in caerulein-stimulated pancreatic weight, protein, and DNA contents. In conclusion, PYY has an inhibitory effect on cholecystokinin-stimulated pancreatic growth and may play a physiological role as an inhibitor of pancreatic growth.

    Original languageEnglish (US)
    Pages (from-to)219-223
    Number of pages5
    JournalEndocrinology
    Volume132
    Issue number1
    StatePublished - Jan 1993

    Fingerprint

    Peptide YY
    Intestines
    Ceruletide
    Pancreas
    Weights and Measures
    RNA
    DNA
    Growth
    Proteins
    Growth Inhibitors
    Cholecystokinin
    Jugular Veins
    Wistar Rats
    Immune Sera
    Peptides

    ASJC Scopus subject areas

    • Endocrinology
    • Endocrinology, Diabetes and Metabolism

    Cite this

    Guan, D., Rivard, N., Morisset, J., & Greeley, G. H. (1993). Effects of peptide YY on the growth of the pancreas and intestine. Endocrinology, 132(1), 219-223.

    Effects of peptide YY on the growth of the pancreas and intestine. / Guan, Difu; Rivard, Nathalie; Morisset, Jean; Greeley, George H.

    In: Endocrinology, Vol. 132, No. 1, 01.1993, p. 219-223.

    Research output: Contribution to journalArticle

    Guan, D, Rivard, N, Morisset, J & Greeley, GH 1993, 'Effects of peptide YY on the growth of the pancreas and intestine', Endocrinology, vol. 132, no. 1, pp. 219-223.
    Guan D, Rivard N, Morisset J, Greeley GH. Effects of peptide YY on the growth of the pancreas and intestine. Endocrinology. 1993 Jan;132(1):219-223.
    Guan, Difu ; Rivard, Nathalie ; Morisset, Jean ; Greeley, George H. / Effects of peptide YY on the growth of the pancreas and intestine. In: Endocrinology. 1993 ; Vol. 132, No. 1. pp. 219-223.
    @article{05d4f07c50bb43b0b16b04b9fb093078,
    title = "Effects of peptide YY on the growth of the pancreas and intestine",
    abstract = "The effects of Peptide YY (PYY) on pancreatic and intestinal growth have been investigated in conscious rats. Male Wistar rats equipped with jugular vein cannulas were randomly assigned to five groups. All rats received continuous iv infusion of gut peptides for 4 days, rats were then killed, and the pancreas and intestine were analyzed. Infusion of PYY alone at the dose of 400 pmol/kg · h affected neither pancreatic weight, DNA and RNA contents, or the duodenal weight, protein, DNA and RNA contents. Infusion of caerulein at the dose of 0.25 μg/kg · h significantly increased pancreatic weight, DNA, RNA, and protein contents by 202{\%}, 109{\%}, 171{\%}, 183{\%} above control values, but it did not affect duodenal weight, DNA, RNA, and protein contents. PYY, 400 pmol/kg · h, infused simultaneously with caerulein significantly reduced by 39{\%}, 35{\%}, and 45{\%} increases in pancreatic weight, RNA and DNA contents stimulated by caerulein, respectively. Surprisingly, administration of PYY antiserum also resulted in a small but significant reduction in caerulein-stimulated pancreatic weight, protein, and DNA contents. In conclusion, PYY has an inhibitory effect on cholecystokinin-stimulated pancreatic growth and may play a physiological role as an inhibitor of pancreatic growth.",
    author = "Difu Guan and Nathalie Rivard and Jean Morisset and Greeley, {George H.}",
    year = "1993",
    month = "1",
    language = "English (US)",
    volume = "132",
    pages = "219--223",
    journal = "Endocrinology",
    issn = "0013-7227",
    publisher = "The Endocrine Society",
    number = "1",

    }

    TY - JOUR

    T1 - Effects of peptide YY on the growth of the pancreas and intestine

    AU - Guan, Difu

    AU - Rivard, Nathalie

    AU - Morisset, Jean

    AU - Greeley, George H.

    PY - 1993/1

    Y1 - 1993/1

    N2 - The effects of Peptide YY (PYY) on pancreatic and intestinal growth have been investigated in conscious rats. Male Wistar rats equipped with jugular vein cannulas were randomly assigned to five groups. All rats received continuous iv infusion of gut peptides for 4 days, rats were then killed, and the pancreas and intestine were analyzed. Infusion of PYY alone at the dose of 400 pmol/kg · h affected neither pancreatic weight, DNA and RNA contents, or the duodenal weight, protein, DNA and RNA contents. Infusion of caerulein at the dose of 0.25 μg/kg · h significantly increased pancreatic weight, DNA, RNA, and protein contents by 202%, 109%, 171%, 183% above control values, but it did not affect duodenal weight, DNA, RNA, and protein contents. PYY, 400 pmol/kg · h, infused simultaneously with caerulein significantly reduced by 39%, 35%, and 45% increases in pancreatic weight, RNA and DNA contents stimulated by caerulein, respectively. Surprisingly, administration of PYY antiserum also resulted in a small but significant reduction in caerulein-stimulated pancreatic weight, protein, and DNA contents. In conclusion, PYY has an inhibitory effect on cholecystokinin-stimulated pancreatic growth and may play a physiological role as an inhibitor of pancreatic growth.

    AB - The effects of Peptide YY (PYY) on pancreatic and intestinal growth have been investigated in conscious rats. Male Wistar rats equipped with jugular vein cannulas were randomly assigned to five groups. All rats received continuous iv infusion of gut peptides for 4 days, rats were then killed, and the pancreas and intestine were analyzed. Infusion of PYY alone at the dose of 400 pmol/kg · h affected neither pancreatic weight, DNA and RNA contents, or the duodenal weight, protein, DNA and RNA contents. Infusion of caerulein at the dose of 0.25 μg/kg · h significantly increased pancreatic weight, DNA, RNA, and protein contents by 202%, 109%, 171%, 183% above control values, but it did not affect duodenal weight, DNA, RNA, and protein contents. PYY, 400 pmol/kg · h, infused simultaneously with caerulein significantly reduced by 39%, 35%, and 45% increases in pancreatic weight, RNA and DNA contents stimulated by caerulein, respectively. Surprisingly, administration of PYY antiserum also resulted in a small but significant reduction in caerulein-stimulated pancreatic weight, protein, and DNA contents. In conclusion, PYY has an inhibitory effect on cholecystokinin-stimulated pancreatic growth and may play a physiological role as an inhibitor of pancreatic growth.

    UR - http://www.scopus.com/inward/record.url?scp=0027463425&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0027463425&partnerID=8YFLogxK

    M3 - Article

    C2 - 7678215

    AN - SCOPUS:0027463425

    VL - 132

    SP - 219

    EP - 223

    JO - Endocrinology

    JF - Endocrinology

    SN - 0013-7227

    IS - 1

    ER -