Effects of phencyclidine on the release and synthesis of newly formed dopamine

T. W. Vickroy, K. M. Johnson

Research output: Contribution to journalArticle

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Abstract

The effect of phencyclidine (PCP) on the release and synthesis of [3H]-dopamine ([3H]-DA) newly synthesized from [3,5-3H]-l-tyrosine was studied under both basal and potassium-stimulated conditions in slices from the rat striatum. Phencyclidine (3-100 μM) stimulated the release of [3H]-DA during superfusion with low level potassium (4.5 mM) buffer, but had no effect on the release of [3H]-DA elicited by superfusion with buffer containing 40 mM potassium. On the other hand, phenycyclidine had no effect (except at 100 μm) on the spontaneous release of [3H]-H2O (formed as a result of the hydroxylation of [3,5-3H]-l-tyrosine), but inhibited the increase in formation of [3H]-H2O normally associated with potassium-induced depolarization. These data are discussed in relation to results obtained with phencyclidine on other in vitro and in vivo models of dopaminergic function.

Original languageEnglish (US)
Pages (from-to)839-842
Number of pages4
JournalNeuropharmacology
Volume22
Issue number7
DOIs
StatePublished - Jul 1983

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Keywords

  • dopamine synthesis
  • phencyclidine
  • release
  • striatum

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

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