Effects of phencyclidine (PCP)-like drugs on turning behavior, 3H-dopamine uptake, and 3H-PCP binding

Kenneth M. Johnson, Lawrence D. Snell

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

In this study representatives from three chemical classes which are known to produce a phencyclidine (PCP)-like discriminative stimulus cue in rats were tested for their ability to inhibit synaptosomal uptake of 3H-dopamine (3H-DA) and to compete for a binding site labeled with 3H-PCP. Although there was a good correlation between these two in vitro activities within the arylcycloalkylamine class (PCP, N-ethyl-phenylcyclohexylamine (PCE), and ketamine) it did not hold when representatives from the benzomorphans, N-allylnormetazocine (NANM), cyclazocine (CYCL), and ethylketocyclazocine (EKC), or a substituted dioxolane (etoxadrol) were included. At some dose each of these drugs with the exception of EKC also produced ipsilateral turning in rats with a unilateral 6-hydroxydopamine lesion of the substantia nigra. This effect was also not well correlated with inhibition of 3H-DA uptake. However, a significant correlation was found to exist between turning behavior and affinity for the putative PCP/sigma receptor. The possibility that a non-dopaminergic mechanism involving the PCP/sigma receptor underlies the ability of these agents to induce turning behavior is discussed.

Original languageEnglish (US)
Pages (from-to)731-735
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Volume22
Issue number5
DOIs
StatePublished - May 1985

Keywords

  • H-Phencyclidine binding
  • Cyclazocine
  • Dopamine uptake
  • Ethylketocyclazocine
  • Etoxadrol
  • Ketamine
  • N-Allylnormetazocine
  • Phencyclidine
  • Turning behavior

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

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