Effects of prematurity on the immunologic system in human milk

Armond S. Goldman, Cutberto Garza, Buford Nichols, Carmen A. Johnson, E. O Brian Smith, Randall M. Goldblum

Research output: Contribution to journalArticle

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Abstract

A longitudinal study of the effect of prematurity on the development of several components of the immunologic system in human milk was performed. Milk was obtained during the second through the twelfth week after parturition. The mean concentrations of lactoferrin and lysozyme were greater in preterm than in term milk during each interval of lactation. The patterns of change in these components were similar for term and preterm milk. Secretory IgA was the predominant form of IgA in preterm milk. The mean concentrations of IgA were greater in preterm milk throughout the study period. Furthermore, total and secretory IgA levels in preterm milk rose linearly during the sixth through the twelfth week, whereas the concentrations of IgA did not change in term milk during that period. In most preterm mothers, secretory IgA antibodies to Escherichia coli somatic antigens increased as lactation proceeded. These increments in specific antibodies usually did not correlate with changes in total secretory IgA. In addition, leukocyte counts in preterm milk were usually lower at two weeks and higher at 12 weeks than in term milk. Thus the concentrations of certain components of the immunologic system in human milk are altered by premature delivery. A decrease in milk volume may account for some changes, whereas certain alterations may be the result of other consequences of premature delivery or less stimulation by the premature infant.

Original languageEnglish (US)
Pages (from-to)901-905
Number of pages5
JournalThe Journal of pediatrics
Volume101
Issue number6
DOIs
StatePublished - 1982

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Human Milk
Milk
Secretory Immunoglobulin A
Immunoglobulin A
Lactation
Lactoferrin
Antibodies
Muramidase
Leukocyte Count
Premature Infants
Longitudinal Studies
Mothers
Parturition
Escherichia coli
Antigens

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Goldman, A. S., Garza, C., Nichols, B., Johnson, C. A., Smith, E. O. B., & Goldblum, R. M. (1982). Effects of prematurity on the immunologic system in human milk. The Journal of pediatrics, 101(6), 901-905. https://doi.org/10.1016/S0022-3476(82)80007-3

Effects of prematurity on the immunologic system in human milk. / Goldman, Armond S.; Garza, Cutberto; Nichols, Buford; Johnson, Carmen A.; Smith, E. O Brian; Goldblum, Randall M.

In: The Journal of pediatrics, Vol. 101, No. 6, 1982, p. 901-905.

Research output: Contribution to journalArticle

Goldman, AS, Garza, C, Nichols, B, Johnson, CA, Smith, EOB & Goldblum, RM 1982, 'Effects of prematurity on the immunologic system in human milk', The Journal of pediatrics, vol. 101, no. 6, pp. 901-905. https://doi.org/10.1016/S0022-3476(82)80007-3
Goldman AS, Garza C, Nichols B, Johnson CA, Smith EOB, Goldblum RM. Effects of prematurity on the immunologic system in human milk. The Journal of pediatrics. 1982;101(6):901-905. https://doi.org/10.1016/S0022-3476(82)80007-3
Goldman, Armond S. ; Garza, Cutberto ; Nichols, Buford ; Johnson, Carmen A. ; Smith, E. O Brian ; Goldblum, Randall M. / Effects of prematurity on the immunologic system in human milk. In: The Journal of pediatrics. 1982 ; Vol. 101, No. 6. pp. 901-905.
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