Effects of recombinant human growth hormone on donor-site healing in severely burned children

D. N. Herndon, R. E. Barrow, K. R. Kunkel, L. Broemeling, R. L. Rutan

Research output: Contribution to journalArticle

324 Scopus citations

Abstract

The beneficial effects of growth hormone on wound healing in severely burned children were studied. Forty patients who were 2 to 18 years old, with 40% or more total body surface area (TBSA) and 20% or more TBSA full-thickness flame or scald burns, were randomized in a double-blind study to receive placebo or 0.1 mg/kg/day recombinant human growth hormone (rHGH) until the first donor site healed or to receive 0.2 mg/kg/day rHGH or placebo from admission throughout hospitalization. Patients receiving 0.2 mg/kg/day rHGH demonstrated significantly higher serum IGF-1 levels at 4.8 ± 1.7 U/mL compared to placebos at 1.6 ± 0.4 U/mL (p < 0.05) and a significant decrease in donor-site healing times compared to placebo (p < 0.05). Length of hospital stay (LOS/%TBSA) was decreased from 0.80 ± 0.10 days/%TBSA burned in the placebo group to 0.54 ± 0.04 days/%TBSA burned in the 0.2 mg/kg/day treatment group (p < 0.05). This translates, for the average 60% TBSA burned patient, to a decrease in LOS from 46 to 32 days.

Original languageEnglish (US)
Pages (from-to)424-431
Number of pages8
JournalAnnals of surgery
Volume212
Issue number4
DOIs
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

Fingerprint Dive into the research topics of 'Effects of recombinant human growth hormone on donor-site healing in severely burned children'. Together they form a unique fingerprint.

  • Cite this

    Herndon, D. N., Barrow, R. E., Kunkel, K. R., Broemeling, L., & Rutan, R. L. (1990). Effects of recombinant human growth hormone on donor-site healing in severely burned children. Annals of surgery, 212(4), 424-431. https://doi.org/10.1097/00000658-199010000-00005