Effects of red blood cell transfusion on resting energy expenditure in adolescents with sickle cell anemia

Paul Harmatz, Melvin B. Heyman, John Cunningham, Philip D.K. Lee, Lori Styles, Keith Quirolo, Lori Kopp-Hoolihan, Jim Ghiron, Raymond L. Hintz, Elliott Vichinsky

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10 Scopus citations

Abstract

Background: Previous studies indicate that resting energy expenditure is elevated in children with sickle cell anemia, possibly caused in part by hemolysis and increased erythropoietic activity. The purpose of the present investigation was to determine whether erythrocyte transfusion normalizes resting energy expenditure in sickle cell anemia. Methods: Five adolescents with sickle cell anemia (12-16 years old; 4 boys, 1 girl) were studied before and 1 week after erythrocyte transfusion before elective surgery or at the initial transfusion for growth failure. Resting energy expenditure was measured by indirect calorimetry, and laboratory measures were determined by routine, validated methods. Data comparisons were by nonparametric analysis. Results: After erythrocyte transfusion, total hemoglobin levels increased (difference (D) = 15 g/l; p < 0.05), whereas hemoglobin S (D = -0.36; p < 0.05) and reticulocyte count (D = -0.12; p < 0.05) decreased. Mean pretransfusion resting energy expenditure was elevated to 124% above predicted levels (p < 0.05) and increased further to 134% above prediction (p < 0.05 vs. pretransfusion levels). Plasma triiodothyronine (T3) levels increased (D = 0.17 nmol/l; p < 0.05), reverse T3 (rT3) levels tended to decline (D = -0.04 nmol/l; p = 0.14), and rT3/T3 decreased (D= -0.03; p < 0.05). Plasma insulin-like growth factor-I (IGF-I) levels were low-normal before transfusion and did not change, despite the change in resting energy expenditure. Conclusions: The results confirm that resting energy expenditure is elevated in patients with sickle cell anemia. However, resting energy expenditure further increased after transfusion, despite decreased erythropoietic activity. A posttransfusion decrease in rT3/T3 may contribute to the increased resting energy expenditure. That there was no change in IGF- I implies that the growth hormone-IGF system is not involved in posttransfusion regulation of resting energy expenditure. Therefore, our data are not consistent with the hypothesis that increased resting energy expenditure in sickle cell anemia is directly related to erythropoietic activity. The mechanisms by which resting energy expenditure increases after transfusion in sickle cell anemia require additional investigation. (C) 2000 Lippincott Williams and Wilkins, Inc.

Original languageEnglish (US)
Pages (from-to)127-131
Number of pages5
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume29
Issue number2
DOIs
StatePublished - Aug 1 1999
Externally publishedYes

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Keywords

  • Erythrocyte transfusion
  • Resting energy expenditure
  • Sickle cell anemia.

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology

Cite this

Harmatz, P., Heyman, M. B., Cunningham, J., Lee, P. D. K., Styles, L., Quirolo, K., Kopp-Hoolihan, L., Ghiron, J., Hintz, R. L., & Vichinsky, E. (1999). Effects of red blood cell transfusion on resting energy expenditure in adolescents with sickle cell anemia. Journal of Pediatric Gastroenterology and Nutrition, 29(2), 127-131. https://doi.org/10.1097/00005176-199908000-00006