Effects of repeated administration of the monoamine oxidase inhibitor phenelzine on the discriminability of d-lysergic acid diethylamide (LSD) and 1-(m-trifluoromethylphenyl) piperazine (TFMPP)

Kathryn Cunningham, Brenda A. Carroll, James B. Appel

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Rats trained to discriminate d-lysergic acid diethylamide (LSD; 0.08 mg/kg) or 1-(m-trifluoromethylphenyl) piperazine (TFMPP; 0.8 mg/kg) were treated with the monoamine oxidase inhibitor (MAOI) phenelzine (10 mg/kg/day) for 7 days. After a 24 h "washout" period, they were challenged with the training drug (and dose) or saline, during extinction test sessions. Following 0.08 mg/kg LSD, LSD-trained rats responded primarily on the saline lever (29% drug-appropriate responding) while, after TFMPP (0.8 mg/kg), TFMPP-trained animals responded on the drug lever (75% drug-appropriate responding). These preliminary data suggest that, if serotonin receptors are involved in the behavioral effects of TFMPP, these receptors differ from those involved in the effects of LSD.

Original languageEnglish (US)
Pages (from-to)134-135
Number of pages2
JournalPsychopharmacology
Volume89
Issue number1
DOIs
StatePublished - May 1986
Externally publishedYes

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Phenelzine
Lysergic Acid Diethylamide
Monoamine Oxidase Inhibitors
Pharmaceutical Preparations
Serotonin Receptors
1-(3-trifluoromethylphenyl)piperazine

Keywords

  • Drug discrimination
  • LSD
  • MAOI
  • Serotonin
  • TFMPP

ASJC Scopus subject areas

  • Pharmacology

Cite this

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author = "Kathryn Cunningham and Carroll, {Brenda A.} and Appel, {James B.}",
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AU - Cunningham, Kathryn

AU - Carroll, Brenda A.

AU - Appel, James B.

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N2 - Rats trained to discriminate d-lysergic acid diethylamide (LSD; 0.08 mg/kg) or 1-(m-trifluoromethylphenyl) piperazine (TFMPP; 0.8 mg/kg) were treated with the monoamine oxidase inhibitor (MAOI) phenelzine (10 mg/kg/day) for 7 days. After a 24 h "washout" period, they were challenged with the training drug (and dose) or saline, during extinction test sessions. Following 0.08 mg/kg LSD, LSD-trained rats responded primarily on the saline lever (29% drug-appropriate responding) while, after TFMPP (0.8 mg/kg), TFMPP-trained animals responded on the drug lever (75% drug-appropriate responding). These preliminary data suggest that, if serotonin receptors are involved in the behavioral effects of TFMPP, these receptors differ from those involved in the effects of LSD.

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