TY - JOUR
T1 - Effects of serotonin depletion on the hippocampal GR/MR and BDNF expression during the stress adaptation
AU - Zhou, Jiansong
AU - Li, Lingjiang
AU - Tang, Shaojun
AU - Cao, Xia
AU - Li, Zexuan
AU - Li, Weihui
AU - Li, Changqi
AU - Zhang, Xianghui
PY - 2008/12/16
Y1 - 2008/12/16
N2 - Increased serotonin (5-hydroxytryptamine, 5-HT) release in the hippocampus induced by repeated stress is thought to be critical for the neuroadaptation that alleviates the adverse effects of stressors on emotion and behavior. A failure in this process may be one of the primary neuropathological mechanisms underlying the development of stress-related disorders. The para-chloroamphetamine (p-PCA) was used to deplete 5-HT in the rat prior to repeated restraint stress (6 h/day for 10 days), and determined the consequences of 5-HT depletion on stress-induced alterations of animal behaviors, hippocampal corticosteroid receptor immunoreactivity and the brain-derived neurotrophic factor (BDNF) mRNA expression. Behavioral tests indicate that the stressed rats with 5-HT depletion showed pronounced anxiety, reduced reward sensitivity and enhanced learned-helplessness. In addition, they also developed learning impairments in Morris water maze tests. These results suggest that hippocampal 5-HT depletion compromised adaptation to chronic stress. Furthermore, repeated stress caused a lesser degree of glucocorticoid receptor increase and down-regulation of BDNF mRNA. The study suggest that 5-HT deficiency in the adult hippocampus may impair stress adaptation by suppressing hippocampal GR and BDNF expression.
AB - Increased serotonin (5-hydroxytryptamine, 5-HT) release in the hippocampus induced by repeated stress is thought to be critical for the neuroadaptation that alleviates the adverse effects of stressors on emotion and behavior. A failure in this process may be one of the primary neuropathological mechanisms underlying the development of stress-related disorders. The para-chloroamphetamine (p-PCA) was used to deplete 5-HT in the rat prior to repeated restraint stress (6 h/day for 10 days), and determined the consequences of 5-HT depletion on stress-induced alterations of animal behaviors, hippocampal corticosteroid receptor immunoreactivity and the brain-derived neurotrophic factor (BDNF) mRNA expression. Behavioral tests indicate that the stressed rats with 5-HT depletion showed pronounced anxiety, reduced reward sensitivity and enhanced learned-helplessness. In addition, they also developed learning impairments in Morris water maze tests. These results suggest that hippocampal 5-HT depletion compromised adaptation to chronic stress. Furthermore, repeated stress caused a lesser degree of glucocorticoid receptor increase and down-regulation of BDNF mRNA. The study suggest that 5-HT deficiency in the adult hippocampus may impair stress adaptation by suppressing hippocampal GR and BDNF expression.
KW - Adaptation
KW - BDNF
KW - Glucocorticoid receptor
KW - Hippocampus
KW - Stress
UR - http://www.scopus.com/inward/record.url?scp=52949115285&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=52949115285&partnerID=8YFLogxK
U2 - 10.1016/j.bbr.2008.06.009
DO - 10.1016/j.bbr.2008.06.009
M3 - Article
C2 - 18601957
AN - SCOPUS:52949115285
SN - 0166-4328
VL - 195
SP - 129
EP - 138
JO - Behavioural Brain Research
JF - Behavioural Brain Research
IS - 1
ER -