Effects of serotonin depletion on the hippocampal GR/MR and BDNF expression during the stress adaptation

Jiansong Zhou, Lingjiang Li, Shao-Jun Tang, Xia Cao, Zexuan Li, Weihui Li, Changqi Li, Xianghui Zhang

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Increased serotonin (5-hydroxytryptamine, 5-HT) release in the hippocampus induced by repeated stress is thought to be critical for the neuroadaptation that alleviates the adverse effects of stressors on emotion and behavior. A failure in this process may be one of the primary neuropathological mechanisms underlying the development of stress-related disorders. The para-chloroamphetamine (p-PCA) was used to deplete 5-HT in the rat prior to repeated restraint stress (6 h/day for 10 days), and determined the consequences of 5-HT depletion on stress-induced alterations of animal behaviors, hippocampal corticosteroid receptor immunoreactivity and the brain-derived neurotrophic factor (BDNF) mRNA expression. Behavioral tests indicate that the stressed rats with 5-HT depletion showed pronounced anxiety, reduced reward sensitivity and enhanced learned-helplessness. In addition, they also developed learning impairments in Morris water maze tests. These results suggest that hippocampal 5-HT depletion compromised adaptation to chronic stress. Furthermore, repeated stress caused a lesser degree of glucocorticoid receptor increase and down-regulation of BDNF mRNA. The study suggest that 5-HT deficiency in the adult hippocampus may impair stress adaptation by suppressing hippocampal GR and BDNF expression.

Original languageEnglish (US)
Pages (from-to)129-138
Number of pages10
JournalBehavioural Brain Research
Volume195
Issue number1
DOIs
StatePublished - Dec 16 2008
Externally publishedYes

Fingerprint

Brain-Derived Neurotrophic Factor
Serotonin
Hippocampus
p-Chloroamphetamine
Learned Helplessness
Animal Behavior
Messenger RNA
Passive Cutaneous Anaphylaxis
Steroid Receptors
Glucocorticoid Receptors
Reward
Emotions
Down-Regulation
Anxiety
Learning
Water

Keywords

  • Adaptation
  • BDNF
  • Glucocorticoid receptor
  • Hippocampus
  • Stress

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Effects of serotonin depletion on the hippocampal GR/MR and BDNF expression during the stress adaptation. / Zhou, Jiansong; Li, Lingjiang; Tang, Shao-Jun; Cao, Xia; Li, Zexuan; Li, Weihui; Li, Changqi; Zhang, Xianghui.

In: Behavioural Brain Research, Vol. 195, No. 1, 16.12.2008, p. 129-138.

Research output: Contribution to journalArticle

Zhou, Jiansong ; Li, Lingjiang ; Tang, Shao-Jun ; Cao, Xia ; Li, Zexuan ; Li, Weihui ; Li, Changqi ; Zhang, Xianghui. / Effects of serotonin depletion on the hippocampal GR/MR and BDNF expression during the stress adaptation. In: Behavioural Brain Research. 2008 ; Vol. 195, No. 1. pp. 129-138.
@article{2308d1a4c17b421cb3bed034a1edc9f1,
title = "Effects of serotonin depletion on the hippocampal GR/MR and BDNF expression during the stress adaptation",
abstract = "Increased serotonin (5-hydroxytryptamine, 5-HT) release in the hippocampus induced by repeated stress is thought to be critical for the neuroadaptation that alleviates the adverse effects of stressors on emotion and behavior. A failure in this process may be one of the primary neuropathological mechanisms underlying the development of stress-related disorders. The para-chloroamphetamine (p-PCA) was used to deplete 5-HT in the rat prior to repeated restraint stress (6 h/day for 10 days), and determined the consequences of 5-HT depletion on stress-induced alterations of animal behaviors, hippocampal corticosteroid receptor immunoreactivity and the brain-derived neurotrophic factor (BDNF) mRNA expression. Behavioral tests indicate that the stressed rats with 5-HT depletion showed pronounced anxiety, reduced reward sensitivity and enhanced learned-helplessness. In addition, they also developed learning impairments in Morris water maze tests. These results suggest that hippocampal 5-HT depletion compromised adaptation to chronic stress. Furthermore, repeated stress caused a lesser degree of glucocorticoid receptor increase and down-regulation of BDNF mRNA. The study suggest that 5-HT deficiency in the adult hippocampus may impair stress adaptation by suppressing hippocampal GR and BDNF expression.",
keywords = "Adaptation, BDNF, Glucocorticoid receptor, Hippocampus, Stress",
author = "Jiansong Zhou and Lingjiang Li and Shao-Jun Tang and Xia Cao and Zexuan Li and Weihui Li and Changqi Li and Xianghui Zhang",
year = "2008",
month = "12",
day = "16",
doi = "10.1016/j.bbr.2008.06.009",
language = "English (US)",
volume = "195",
pages = "129--138",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Effects of serotonin depletion on the hippocampal GR/MR and BDNF expression during the stress adaptation

AU - Zhou, Jiansong

AU - Li, Lingjiang

AU - Tang, Shao-Jun

AU - Cao, Xia

AU - Li, Zexuan

AU - Li, Weihui

AU - Li, Changqi

AU - Zhang, Xianghui

PY - 2008/12/16

Y1 - 2008/12/16

N2 - Increased serotonin (5-hydroxytryptamine, 5-HT) release in the hippocampus induced by repeated stress is thought to be critical for the neuroadaptation that alleviates the adverse effects of stressors on emotion and behavior. A failure in this process may be one of the primary neuropathological mechanisms underlying the development of stress-related disorders. The para-chloroamphetamine (p-PCA) was used to deplete 5-HT in the rat prior to repeated restraint stress (6 h/day for 10 days), and determined the consequences of 5-HT depletion on stress-induced alterations of animal behaviors, hippocampal corticosteroid receptor immunoreactivity and the brain-derived neurotrophic factor (BDNF) mRNA expression. Behavioral tests indicate that the stressed rats with 5-HT depletion showed pronounced anxiety, reduced reward sensitivity and enhanced learned-helplessness. In addition, they also developed learning impairments in Morris water maze tests. These results suggest that hippocampal 5-HT depletion compromised adaptation to chronic stress. Furthermore, repeated stress caused a lesser degree of glucocorticoid receptor increase and down-regulation of BDNF mRNA. The study suggest that 5-HT deficiency in the adult hippocampus may impair stress adaptation by suppressing hippocampal GR and BDNF expression.

AB - Increased serotonin (5-hydroxytryptamine, 5-HT) release in the hippocampus induced by repeated stress is thought to be critical for the neuroadaptation that alleviates the adverse effects of stressors on emotion and behavior. A failure in this process may be one of the primary neuropathological mechanisms underlying the development of stress-related disorders. The para-chloroamphetamine (p-PCA) was used to deplete 5-HT in the rat prior to repeated restraint stress (6 h/day for 10 days), and determined the consequences of 5-HT depletion on stress-induced alterations of animal behaviors, hippocampal corticosteroid receptor immunoreactivity and the brain-derived neurotrophic factor (BDNF) mRNA expression. Behavioral tests indicate that the stressed rats with 5-HT depletion showed pronounced anxiety, reduced reward sensitivity and enhanced learned-helplessness. In addition, they also developed learning impairments in Morris water maze tests. These results suggest that hippocampal 5-HT depletion compromised adaptation to chronic stress. Furthermore, repeated stress caused a lesser degree of glucocorticoid receptor increase and down-regulation of BDNF mRNA. The study suggest that 5-HT deficiency in the adult hippocampus may impair stress adaptation by suppressing hippocampal GR and BDNF expression.

KW - Adaptation

KW - BDNF

KW - Glucocorticoid receptor

KW - Hippocampus

KW - Stress

UR - http://www.scopus.com/inward/record.url?scp=52949115285&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=52949115285&partnerID=8YFLogxK

U2 - 10.1016/j.bbr.2008.06.009

DO - 10.1016/j.bbr.2008.06.009

M3 - Article

VL - 195

SP - 129

EP - 138

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

IS - 1

ER -