TY - JOUR
T1 - Effects of sigma ligands on mouse cerebellar cyclic guanosine monophosphate (cGMP) levels in vivo
T2 - further evidence for a functional modulation of N-methyl-d-aspartate (NMDA) receptor complex-mediated events by sigma ligands
AU - Rao, Tadimeti S.
AU - Mick, Steve J.
AU - Cler, Julie A.
AU - Emmett, Mark R.
AU - Dilworth, Vickie M.
AU - Contreras, Patricia C.
AU - Gray, Nancy M.
AU - Wood, Paul L.
AU - Iyengar, Smriti
PY - 1991/10/4
Y1 - 1991/10/4
N2 - In the present investigation, the effects of sigma ligands [WY-47384 {;8-fluoro-2,3,4,5-tetrahydro-2[3-(3-pyridinyl)propyl)1H- pyrido(4, 3b)indole}, (+)-pentazocine, (+)-SFK 10,047 (N-allylnormetazocine), mafoprazine, opipramol, dextromethorphan, dextrorphan, (+)-3-PPP [3-(3-hydroxyphenyl)-N-propylpiperidine], (-)-butaclamol, DTG [1,3-di(2-tolyl)guanidine], rimcazole, ifenprodil and BMY-14802 {α-(fluorophenyl)-4-(5-fluoropyrimidinyl)-1-piperazine butanol}] on harmaline-, pentylenetetrazol (PTZ)-, methamphetamine (MA)- and d-serine-induced increases in mouse cerebellar levels of cGMP were determined. Ifenprodil, BMY-14802, dextromethorphan, dextrorphan, (+)-SKF 10,047, opipramol and mafoprazine reversed harmaline-, PTZ-, MA- and d-serine-induced increases in levels of cGMP. Rimcazole reversed only the harmaline-induced response. WY-47384 reversed harmaline-, MA-, d-serine-, but not PTZ- or quisqualate-induced increases in levels of cGMP. (+)-Pentazocine attenuated harmaline- and d-serine-, but not PTZ- and MA-induced cGMP responses. Haloperidol did not affect harmaline- and d-serine-induced cGMP responses. (+)-3-PPP and (-)-butaclamol did not affect any of the responses studied. Furthermore, (+)-3-PPP-induced increases in levels of cGMP were reversed by the competitive N-methyl-d-aspartate (NMDA) antagonist, CPP} 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid, the non-competitive NMDA antagonist, (+)-MK-801 (dizocilipine maleate), the NMDA-associated glycine receptor antagonist, HA-966 (3-amino-1-hydroxypyrrolidin-2-one), the partial glycine agonist, DCS (d-cycloserine) as well as by the sigma ligands, ifenprodil, WY-47384, (+)-pentazocine, (+)-SKF 10,047, dextromethorphan and dextrorphan but not by rimcazole. These data further support functional modulation by sigma ligands of events mediated by the NMDA receptor complex established in earlier investigations.
AB - In the present investigation, the effects of sigma ligands [WY-47384 {;8-fluoro-2,3,4,5-tetrahydro-2[3-(3-pyridinyl)propyl)1H- pyrido(4, 3b)indole}, (+)-pentazocine, (+)-SFK 10,047 (N-allylnormetazocine), mafoprazine, opipramol, dextromethorphan, dextrorphan, (+)-3-PPP [3-(3-hydroxyphenyl)-N-propylpiperidine], (-)-butaclamol, DTG [1,3-di(2-tolyl)guanidine], rimcazole, ifenprodil and BMY-14802 {α-(fluorophenyl)-4-(5-fluoropyrimidinyl)-1-piperazine butanol}] on harmaline-, pentylenetetrazol (PTZ)-, methamphetamine (MA)- and d-serine-induced increases in mouse cerebellar levels of cGMP were determined. Ifenprodil, BMY-14802, dextromethorphan, dextrorphan, (+)-SKF 10,047, opipramol and mafoprazine reversed harmaline-, PTZ-, MA- and d-serine-induced increases in levels of cGMP. Rimcazole reversed only the harmaline-induced response. WY-47384 reversed harmaline-, MA-, d-serine-, but not PTZ- or quisqualate-induced increases in levels of cGMP. (+)-Pentazocine attenuated harmaline- and d-serine-, but not PTZ- and MA-induced cGMP responses. Haloperidol did not affect harmaline- and d-serine-induced cGMP responses. (+)-3-PPP and (-)-butaclamol did not affect any of the responses studied. Furthermore, (+)-3-PPP-induced increases in levels of cGMP were reversed by the competitive N-methyl-d-aspartate (NMDA) antagonist, CPP} 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid, the non-competitive NMDA antagonist, (+)-MK-801 (dizocilipine maleate), the NMDA-associated glycine receptor antagonist, HA-966 (3-amino-1-hydroxypyrrolidin-2-one), the partial glycine agonist, DCS (d-cycloserine) as well as by the sigma ligands, ifenprodil, WY-47384, (+)-pentazocine, (+)-SKF 10,047, dextromethorphan and dextrorphan but not by rimcazole. These data further support functional modulation by sigma ligands of events mediated by the NMDA receptor complex established in earlier investigations.
KW - Cyclic guanosine monophosphate
KW - Harmaline, Pentylenetetrazol
KW - Methamphetamine, Sigma receptor
KW - N-Methyl-d-aspartate
UR - http://www.scopus.com/inward/record.url?scp=0025988344&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025988344&partnerID=8YFLogxK
U2 - 10.1016/0006-8993(91)90747-J
DO - 10.1016/0006-8993(91)90747-J
M3 - Article
C2 - 1686745
AN - SCOPUS:0025988344
SN - 0006-8993
VL - 561
SP - 43
EP - 50
JO - Brain Research
JF - Brain Research
IS - 1
ER -