Effects of specific opiate agonists on the naloxone-induced release of luteinizing hormone-releasing hormone from the medial basal hypothalamus in vitro

B. T. Miller, T. J. Cicero

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    The effects of specific mu, delta and kappa opiate agonists on the in vitro naloxone-induced release of (LHRH) from the rat medial basal hypothalamus were examined. Naloxone produced a consistent calcium-dependent increase in the release of LHRH. The mu receptor agonist sufentanil was highly effective in inhibiting this increase in LHRH release whereas delta and kappa opiate agonists were ineffective. These results indicate that the effects of naloxone on LHRH release are mediated primarily by mu opiate receptors.

    Original languageEnglish (US)
    Pages (from-to)91-95
    Number of pages5
    JournalNeuroendocrinology Letters
    Volume10
    Issue number2
    StatePublished - 1988

    Fingerprint

    Opiate Alkaloids
    Middle Hypothalamus
    Naloxone
    Gonadotropin-Releasing Hormone
    mu Opioid Receptor
    Sufentanil
    Opioid Receptors
    Calcium
    In Vitro Techniques

    ASJC Scopus subject areas

    • Endocrinology
    • Neuroscience(all)

    Cite this

    Effects of specific opiate agonists on the naloxone-induced release of luteinizing hormone-releasing hormone from the medial basal hypothalamus in vitro. / Miller, B. T.; Cicero, T. J.

    In: Neuroendocrinology Letters, Vol. 10, No. 2, 1988, p. 91-95.

    Research output: Contribution to journalArticle

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