Effects of statins on proinflammatory/prothrombotic biomarkers and on disease activity scores in SLE patients: Data from LUMINA (LXXVI), a multi-ethnic us cohort

Rohan Willis, Alan M. Seif, Gerald McGwin, Laura Aline Martinez-Martinez, Emilio B. González, Ellis Doan, Neha Dang, Elizabeth Papalardo, Jigna Liu, Luis M. Vilá, John D. Reveille, Graciela S. Alarcón, Silvia S. Pierangeli

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Objective: We sought to determine the effect of statin therapy on the levels of proinflammatory /prothrombotic markers and disease activity scores in patients with SLE in a multi-ethnic, multi-centre cohort (LUMINA). Methods: Plasma/serum samples from SLE patients placed on statins (n=21) therapy taken before and after at least 6 months of treatment were tested. Disease activity was assessed using SLAM-R scores. Interleukin (IL)-1β, IL-6, IL-8, tumour necrosis factor (TNF)-a, vascular endothelial growth factor (VEGF) and soluble CD40 ligand (sCD40L) levels were determined by a multiplex immunoassay. Soluble intercellular cell adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1 and anticardiolipin (aCL) antibodies were evaluated using ELISA assays while high sensitivity C-reactive protein (hsCRP) was assessed by nephelometry. Plasma/serum samples from frequency-matched healthy donors were used as controls. Results: Levels of IL-6, VEGF, sCD40L and TNF-a were significantly elevated in SLE patients versus controls. Statin therapy resulted in a significant decrease in SLAM-R scores (p=0.0199) but no significant changes in biomarker levels were observed. There was no significant association of biomarkers with SLAM-R scores. Conclusion: Statin therapy resulted in significant clinical improvement in SLE patients, underscoring the use of statins in the treatment of SLE.

Original languageEnglish (US)
Pages (from-to)162-167
Number of pages6
JournalClinical and Experimental Rheumatology
Volume32
Issue number2
StatePublished - 2014

Keywords

  • Biomarkers of inflammation
  • Biomarkers of thrombosis
  • Lupus
  • Statins

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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    Willis, R., Seif, A. M., McGwin, G., Martinez-Martinez, L. A., González, E. B., Doan, E., Dang, N., Papalardo, E., Liu, J., Vilá, L. M., Reveille, J. D., Alarcón, G. S., & Pierangeli, S. S. (2014). Effects of statins on proinflammatory/prothrombotic biomarkers and on disease activity scores in SLE patients: Data from LUMINA (LXXVI), a multi-ethnic us cohort. Clinical and Experimental Rheumatology, 32(2), 162-167.