Efficacy and toxicity of zinc salts as candidate topical microbicides against vaginal herpes simplex virus type 2 infection

Nigel Bourne, Rachael Stegall, Raquel Montano, Michael Meador, Lawrence R. Stanberry, Gregg N. Milligan

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Zinc salt solutions administered as topical microbicides provided significant protection against herpes simplex virus type 2 infection in a mouse vaginal challenge model. However, at the therapeutic concentration, the salt solutions caused sloughing of sheets of vaginal epithelial cells. These observations limit the utility of zinc salts as microbicides and suggest that the application of zinc solutions to mucosal surfaces has the potential to cause damage that might increase susceptibility to secondary infections at a later time.

Original languageEnglish (US)
Pages (from-to)1181-1183
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume49
Issue number3
DOIs
StatePublished - Mar 2005

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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