Efficacy of a heparin removal device in comparison with protamine after hypothermic cardiopulmonary bypass

Weike Tao, Donald J. Deyo, Robert L. Brunston, Roger A. Vertrees, Tonya L. Grochoske, Joseph B. Zwischenberger

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

To reduce the risks of protamine reactions after cardiopulmonary bypass (CPB), a heparin removal device (HRD) with plasma separation and poly-L-lysine (PLL) affinity adsorption was developed. To compare the efficacy of HRD with that of protamine, blood coagulation variables were evaluated in a swine model of CPB. It is concluded that the HRD is capable of predictable reversal of systemic heparinization after CPB, and is an alternative to achieve heparin clearance in subjects who may develop adverse reactions to protamine.

Original languageEnglish (US)
Pages (from-to)M825-M830
JournalASAIO Journal
Volume43
Issue number5
DOIs
StatePublished - Jan 1 1997

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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    Tao, W., Deyo, D. J., Brunston, R. L., Vertrees, R. A., Grochoske, T. L., & Zwischenberger, J. B. (1997). Efficacy of a heparin removal device in comparison with protamine after hypothermic cardiopulmonary bypass. ASAIO Journal, 43(5), M825-M830. https://doi.org/10.1097/00002480-199709000-00100