Efficacy of a recombinant rift valley fever virus MP-12 with NSm deletion as a vaccine candidate in sheep

Hana M. Weingartl, Charles K. Nfon, Shunzhen Zhang, Peter Marszal, William C. Wilson, John C. Morrill, George E. Bettinger, Clarence J. Peters

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Rift Valley fever virus (RVFV), a mosquito-borne virus in the Bunyaviridae family and Phlebovirus genus, causes RVF, a disease of ruminants and man, endemic in Sub-Saharan African countries. However, outbreaks in Yemen and Saudi Arabia demonstrate the ability for RVFV to spread into virgin territory and thus the need exists to develop safe and efficacious vaccines that can be used outside the endemic zones. Commercial RVFV vaccines are available but have limitations that prevent their use in disease-free countries. Consequently, there are ongoing efforts to develop and/or improve RVFV vaccines with global acceptability. In this study a previously developed MP-12-derived vaccine candidate with a large deletion of the NSm gene in the pre Gn region of the M segment (arMP-12-δNSm21/384) developed by T. Ikegami, that was already shown to be safe in pregnant sheep causing neither abortion nor fetal malformation was further evaluated. This vaccine was tested for protection of sheep from viremia and fever following challenge with virulent RVFV ZH501 strain. A single vaccination with arMP-12-δNSm21/384 fully protected sheep when challenged four weeks post vaccination, thereby demonstrating that this vaccine is efficacious in protecting these animals from RVFV infection.

Original languageEnglish (US)
Pages (from-to)2345-2349
Number of pages5
JournalVaccine
Volume32
Issue number20
DOIs
StatePublished - Apr 25 2014

Keywords

  • NSm deleted MP-12
  • Rift Valley fever
  • Sheep
  • Vaccine

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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  • Cite this

    Weingartl, H. M., Nfon, C. K., Zhang, S., Marszal, P., Wilson, W. C., Morrill, J. C., Bettinger, G. E., & Peters, C. J. (2014). Efficacy of a recombinant rift valley fever virus MP-12 with NSm deletion as a vaccine candidate in sheep. Vaccine, 32(20), 2345-2349. https://doi.org/10.1016/j.vaccine.2013.12.064