Efficacy of a topical combination of fipronil-permethrin against Rhodnius prolixus on dogs

A. Ucan-Mézquita, M. Jimenez-Coello, E. Guzmán-Marín, E. Gutierrez-Blanco, J. I. Chan-Pérez, B. L. Travi, I. Hernandez-Cortazar, A. Ortega-Pacheco

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A controlled clinical trial was carried out to assess the mortality and repellency of a new topical combination of fipronil-permethrin (Effitix® Virbac, Mexico) against Rhodnius prolixus in dogs. Ten medium-size dogs (10−15 kg) with short hair were used. The dogs were exposed to 8 adult triatomines once weekly for 7 weeks. On the control day (D0), the dogs were exposed to the insects without treatment. On D7, the dogs were immediately treated with a spot-on 2.2 ml pipette containing 134 mg of fipronil and 1200 mg permethrin after exposure to the insects. The dose was repeated after 4 weeks following the manufacturer's instructions. Repellency at D0 was, 0 % and the insects had a high blood content. After 12 h post-contact, repellency was 86.3 % and slowly decrease though D21 and D28. On D7, none of the insects survived after 3 h of feeding on the treated dogs. On D14, D35 and D42, all insects died within 12 h post-feeding, whereas no mortality was observed in the control D0 (P < 0.05). The results of this study indicated that administration of the product following the manufacturer's instructions was efficacious at inducing rapid mortality of R. prolixus and therefore could be useful to prevent the transmission of American trypanosomiasis in dogs.

Original languageEnglish (US)
Article number108978
JournalVeterinary Parasitology
Volume276
DOIs
StatePublished - Dec 2019

Fingerprint

Rhodnius
Permethrin
Rhodnius prolixus
fipronil
permethrin
Dogs
Insects
dogs
insects
Mortality
Triatominae
Chagas disease
Chagas Disease
Controlled Clinical Trials
Mexico
Hair
hairs
clinical trials
blood
dosage

Keywords

  • American trypanosomiasis
  • Dogs
  • Fipronil
  • Permethrin
  • Rhodnius prolixus

ASJC Scopus subject areas

  • Parasitology
  • veterinary(all)

Cite this

Ucan-Mézquita, A., Jimenez-Coello, M., Guzmán-Marín, E., Gutierrez-Blanco, E., Chan-Pérez, J. I., Travi, B. L., ... Ortega-Pacheco, A. (2019). Efficacy of a topical combination of fipronil-permethrin against Rhodnius prolixus on dogs. Veterinary Parasitology, 276, [108978]. https://doi.org/10.1016/j.vetpar.2019.108978

Efficacy of a topical combination of fipronil-permethrin against Rhodnius prolixus on dogs. / Ucan-Mézquita, A.; Jimenez-Coello, M.; Guzmán-Marín, E.; Gutierrez-Blanco, E.; Chan-Pérez, J. I.; Travi, B. L.; Hernandez-Cortazar, I.; Ortega-Pacheco, A.

In: Veterinary Parasitology, Vol. 276, 108978, 12.2019.

Research output: Contribution to journalArticle

Ucan-Mézquita, A, Jimenez-Coello, M, Guzmán-Marín, E, Gutierrez-Blanco, E, Chan-Pérez, JI, Travi, BL, Hernandez-Cortazar, I & Ortega-Pacheco, A 2019, 'Efficacy of a topical combination of fipronil-permethrin against Rhodnius prolixus on dogs', Veterinary Parasitology, vol. 276, 108978. https://doi.org/10.1016/j.vetpar.2019.108978
Ucan-Mézquita A, Jimenez-Coello M, Guzmán-Marín E, Gutierrez-Blanco E, Chan-Pérez JI, Travi BL et al. Efficacy of a topical combination of fipronil-permethrin against Rhodnius prolixus on dogs. Veterinary Parasitology. 2019 Dec;276. 108978. https://doi.org/10.1016/j.vetpar.2019.108978
Ucan-Mézquita, A. ; Jimenez-Coello, M. ; Guzmán-Marín, E. ; Gutierrez-Blanco, E. ; Chan-Pérez, J. I. ; Travi, B. L. ; Hernandez-Cortazar, I. ; Ortega-Pacheco, A. / Efficacy of a topical combination of fipronil-permethrin against Rhodnius prolixus on dogs. In: Veterinary Parasitology. 2019 ; Vol. 276.
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