Efficacy of atropine methylnitrate alone and in combination with albuterol in children with asthma

P. Vichyanond, W. A. Sladek, Sanjiv Sur, M. R. Hill, S. J. Szefler, H. S. Nelson

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The bronchodilator effect of nebulized AMN, albuterol and their combination was evaluated in 16 steroid-dependent asthmatic children. In phase 1, maximal bronchodilation was determined by dose-response studies on separate days. Maximal bronchodilator dose of each drug was administered either alone or in combination during phase 2. In phase 1, 0.11±0.01 mg/kg of albuterol and 0.03 mg/kg of AMN produced maximum bronchodilation. In phase 2, the peak response to albuterol occurred within 30 min and to AMN, at 60 min. Maximal FEV1 achieved after AMN was 90 percent of the maximal achieved after albuterol. AMN FEV1 response was better than for placebo for 3 h; that for albuterol was better for 4 h. Combination therapy produced a peak response similar to that of albuterol but was better than albuterol by 6 h. Thus, the maximum bronchodilator effect of AMN is less than that of albuterol in asthmatic children, but the combination may extend the period of bronchodilatation.

Original languageEnglish (US)
Pages (from-to)637-642
Number of pages6
JournalChest
Volume98
Issue number3
StatePublished - 1990
Externally publishedYes

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Albuterol
Atropine
Asthma
Bronchodilator Agents
Steroids
Placebos
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Vichyanond, P., Sladek, W. A., Sur, S., Hill, M. R., Szefler, S. J., & Nelson, H. S. (1990). Efficacy of atropine methylnitrate alone and in combination with albuterol in children with asthma. Chest, 98(3), 637-642.

Efficacy of atropine methylnitrate alone and in combination with albuterol in children with asthma. / Vichyanond, P.; Sladek, W. A.; Sur, Sanjiv; Hill, M. R.; Szefler, S. J.; Nelson, H. S.

In: Chest, Vol. 98, No. 3, 1990, p. 637-642.

Research output: Contribution to journalArticle

Vichyanond, P, Sladek, WA, Sur, S, Hill, MR, Szefler, SJ & Nelson, HS 1990, 'Efficacy of atropine methylnitrate alone and in combination with albuterol in children with asthma', Chest, vol. 98, no. 3, pp. 637-642.
Vichyanond P, Sladek WA, Sur S, Hill MR, Szefler SJ, Nelson HS. Efficacy of atropine methylnitrate alone and in combination with albuterol in children with asthma. Chest. 1990;98(3):637-642.
Vichyanond, P. ; Sladek, W. A. ; Sur, Sanjiv ; Hill, M. R. ; Szefler, S. J. ; Nelson, H. S. / Efficacy of atropine methylnitrate alone and in combination with albuterol in children with asthma. In: Chest. 1990 ; Vol. 98, No. 3. pp. 637-642.
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