Efficacy of cefazolin in promoting ovine tracheal epithelial repair

R. E. Barrow, C. Z. Wang, S. F. Yang, Q. Zhu, R. A. Cox

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Inhalation of toxic materials has been shown injurious to the upper airways. Because secondary infection can slow the repair process, we undertook this study to determine the efficacy of antibiotic therapy in promoting the healing process of acute tracheal wounds. In 18 anesthetized sheep, a portion of the cervical trachea was exposed to smoke from smoldering cotton cooled to 38°C. Nine received the broad-spectrum antibiotic, cefazolin, while none received saline placebo. At 13 days after injury, nonciliated and ciliated cell counts were 75% and 33% respectively of noninjured trachea receiving placebo, while in those receiving cefazolin, nonciliated and ciliated cell counts increased to 93% and 114% of paired noninjured trachea, respectively. We suggest that cefazolin therapy allows cell proliferation and differentiation to proceed more rapidly than observed with placebo therapy and thus may be a helpful augmentor to the healing of an acute airway injury.

Original languageEnglish (US)
Pages (from-to)231-235
Number of pages5
JournalRespiration
Volume61
Issue number4
StatePublished - 1994

Fingerprint

Cefazolin
Trachea
Sheep
Placebos
Wounds and Injuries
Cell Count
Anti-Bacterial Agents
Poisons
Coinfection
Smoke
Inhalation
Cell Differentiation
Therapeutics
Cell Proliferation

Keywords

  • Antibiotic therapy
  • Inhalation injury
  • Tracheal epithelial repair

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine

Cite this

Barrow, R. E., Wang, C. Z., Yang, S. F., Zhu, Q., & Cox, R. A. (1994). Efficacy of cefazolin in promoting ovine tracheal epithelial repair. Respiration, 61(4), 231-235.

Efficacy of cefazolin in promoting ovine tracheal epithelial repair. / Barrow, R. E.; Wang, C. Z.; Yang, S. F.; Zhu, Q.; Cox, R. A.

In: Respiration, Vol. 61, No. 4, 1994, p. 231-235.

Research output: Contribution to journalArticle

Barrow, RE, Wang, CZ, Yang, SF, Zhu, Q & Cox, RA 1994, 'Efficacy of cefazolin in promoting ovine tracheal epithelial repair', Respiration, vol. 61, no. 4, pp. 231-235.
Barrow RE, Wang CZ, Yang SF, Zhu Q, Cox RA. Efficacy of cefazolin in promoting ovine tracheal epithelial repair. Respiration. 1994;61(4):231-235.
Barrow, R. E. ; Wang, C. Z. ; Yang, S. F. ; Zhu, Q. ; Cox, R. A. / Efficacy of cefazolin in promoting ovine tracheal epithelial repair. In: Respiration. 1994 ; Vol. 61, No. 4. pp. 231-235.
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