Efficacy of EHEC gold nanoparticle vaccines evaluated with the Shiga toxin-producing Citrobacter rodentium mouse model

Sarah Bowser, Angela Melton-Celsa, Itziar Chapartegui Gonzalez, Alfredo G. Torres

Research output: Contribution to journalArticlepeer-review

Abstract

IMPORTANCE: Enterohemorrhagic Escherichia coli (EHEC) remains an important cause of diarrheal disease and complications worldwide, especially in children, yet there are no available vaccines for human use. Inadequate pre-clinical evaluation due to inconsistent animal models remains a major barrier to novel vaccine development. We demonstrate the usefulness of Stx2d-producing Citrobacter rodentium in assessing vaccine effectiveness because it more closely recapitulates human disease caused by EHEC.

Original languageEnglish (US)
Pages (from-to)e0226123
JournalMicrobiology Spectrum
Volume12
Issue number1
DOIs
StatePublished - Jan 11 2024
Externally publishedYes

Keywords

  • Citrobacter rodentium
  • EHEC
  • hemolytic uremic syndrome
  • nanovaccines
  • Shiga toxin

ASJC Scopus subject areas

  • Physiology
  • Ecology
  • General Immunology and Microbiology
  • Genetics
  • Microbiology (medical)
  • Cell Biology
  • Infectious Diseases

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