Efficacy of EHEC gold nanoparticle vaccines evaluated with the Shiga toxin-producing Citrobacter rodentium mouse model

Sarah Bowser; Angela Melton-Celsa; Itziar Chapartegui Gonzalez; Alfredo G. Torres

doi:10.1128/spectrum.02261-23

Efficacy of EHEC gold nanoparticle vaccines evaluated with the Shiga toxin-producing Citrobacter rodentium mouse model

Sarah Bowser, Angela Melton-Celsa, Itziar Chapartegui Gonzalez, Alfredo G. Torres

Microbiology And Immunology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

IMPORTANCE: Enterohemorrhagic Escherichia coli (EHEC) remains an important cause of diarrheal disease and complications worldwide, especially in children, yet there are no available vaccines for human use. Inadequate pre-clinical evaluation due to inconsistent animal models remains a major barrier to novel vaccine development. We demonstrate the usefulness of Stx2d-producing Citrobacter rodentium in assessing vaccine effectiveness because it more closely recapitulates human disease caused by EHEC.

Original language	English (US)
Pages (from-to)	e0226123
Journal	Microbiology Spectrum
Volume	12
Issue number	1
DOIs	https://doi.org/10.1128/spectrum.02261-23
State	Published - Jan 11 2024

Keywords

Citrobacter rodentium
EHEC
hemolytic uremic syndrome
nanovaccines
Shiga toxin

ASJC Scopus subject areas

Physiology
Ecology
General Immunology and Microbiology
Genetics
Microbiology (medical)
Cell Biology
Infectious Diseases

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10.1128/spectrum.02261-23

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title = "Efficacy of EHEC gold nanoparticle vaccines evaluated with the Shiga toxin-producing Citrobacter rodentium mouse model",

abstract = "IMPORTANCE: Enterohemorrhagic Escherichia coli (EHEC) remains an important cause of diarrheal disease and complications worldwide, especially in children, yet there are no available vaccines for human use. Inadequate pre-clinical evaluation due to inconsistent animal models remains a major barrier to novel vaccine development. We demonstrate the usefulness of Stx2d-producing Citrobacter rodentium in assessing vaccine effectiveness because it more closely recapitulates human disease caused by EHEC.",

keywords = "Citrobacter rodentium, EHEC, hemolytic uremic syndrome, nanovaccines, Shiga toxin",

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AU - Chapartegui Gonzalez, Itziar

AU - Torres, Alfredo G.

PY - 2024/1/11

Y1 - 2024/1/11

N2 - IMPORTANCE: Enterohemorrhagic Escherichia coli (EHEC) remains an important cause of diarrheal disease and complications worldwide, especially in children, yet there are no available vaccines for human use. Inadequate pre-clinical evaluation due to inconsistent animal models remains a major barrier to novel vaccine development. We demonstrate the usefulness of Stx2d-producing Citrobacter rodentium in assessing vaccine effectiveness because it more closely recapitulates human disease caused by EHEC.

AB - IMPORTANCE: Enterohemorrhagic Escherichia coli (EHEC) remains an important cause of diarrheal disease and complications worldwide, especially in children, yet there are no available vaccines for human use. Inadequate pre-clinical evaluation due to inconsistent animal models remains a major barrier to novel vaccine development. We demonstrate the usefulness of Stx2d-producing Citrobacter rodentium in assessing vaccine effectiveness because it more closely recapitulates human disease caused by EHEC.

KW - Citrobacter rodentium

KW - EHEC

KW - hemolytic uremic syndrome

KW - nanovaccines

KW - Shiga toxin

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Efficacy of EHEC gold nanoparticle vaccines evaluated with the Shiga toxin-producing Citrobacter rodentium mouse model

Abstract

Keywords

ASJC Scopus subject areas

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