Efficacy of herpes simplex virus type 1 immunization in protecting against acute and latent infection by herpes simplex virus type 2 in mice

R. R. McKendall

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

ICR mice were immunized with herpes simplex virus type 1 (HSV-1) and later challenged with HSV-2 by footpad inoculation. Both immunized animals and age-matched, nonimmunized controls were observed for ascending neurological disease and latent infection of spinal ganglia resulting from the HSV-2 challenge. Control animals had a 78% incidence of acute and latent infection compared with a 1.7% incidence in immunized mice. The data show immunity to HSV-1 is protective against both acute and latent infection by HSV-2.

Original languageEnglish (US)
Pages (from-to)717-719
Number of pages3
JournalInfection and Immunity
Volume16
Issue number2
StatePublished - 1977

Fingerprint

Human Herpesvirus 2
Human Herpesvirus 1
Immunization
Infection
Inbred ICR Mouse
Incidence
Spinal Ganglia
Immunity

ASJC Scopus subject areas

  • Immunology

Cite this

Efficacy of herpes simplex virus type 1 immunization in protecting against acute and latent infection by herpes simplex virus type 2 in mice. / McKendall, R. R.

In: Infection and Immunity, Vol. 16, No. 2, 1977, p. 717-719.

Research output: Contribution to journalArticle

@article{2fd7b3a53b1d4baa85484fa10878cf8e,
title = "Efficacy of herpes simplex virus type 1 immunization in protecting against acute and latent infection by herpes simplex virus type 2 in mice",
abstract = "ICR mice were immunized with herpes simplex virus type 1 (HSV-1) and later challenged with HSV-2 by footpad inoculation. Both immunized animals and age-matched, nonimmunized controls were observed for ascending neurological disease and latent infection of spinal ganglia resulting from the HSV-2 challenge. Control animals had a 78{\%} incidence of acute and latent infection compared with a 1.7{\%} incidence in immunized mice. The data show immunity to HSV-1 is protective against both acute and latent infection by HSV-2.",
author = "McKendall, {R. R.}",
year = "1977",
language = "English (US)",
volume = "16",
pages = "717--719",
journal = "Infection and Immunity",
issn = "0019-9567",
publisher = "American Society for Microbiology",
number = "2",

}

TY - JOUR

T1 - Efficacy of herpes simplex virus type 1 immunization in protecting against acute and latent infection by herpes simplex virus type 2 in mice

AU - McKendall, R. R.

PY - 1977

Y1 - 1977

N2 - ICR mice were immunized with herpes simplex virus type 1 (HSV-1) and later challenged with HSV-2 by footpad inoculation. Both immunized animals and age-matched, nonimmunized controls were observed for ascending neurological disease and latent infection of spinal ganglia resulting from the HSV-2 challenge. Control animals had a 78% incidence of acute and latent infection compared with a 1.7% incidence in immunized mice. The data show immunity to HSV-1 is protective against both acute and latent infection by HSV-2.

AB - ICR mice were immunized with herpes simplex virus type 1 (HSV-1) and later challenged with HSV-2 by footpad inoculation. Both immunized animals and age-matched, nonimmunized controls were observed for ascending neurological disease and latent infection of spinal ganglia resulting from the HSV-2 challenge. Control animals had a 78% incidence of acute and latent infection compared with a 1.7% incidence in immunized mice. The data show immunity to HSV-1 is protective against both acute and latent infection by HSV-2.

UR - http://www.scopus.com/inward/record.url?scp=0017664409&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017664409&partnerID=8YFLogxK

M3 - Article

VL - 16

SP - 717

EP - 719

JO - Infection and Immunity

JF - Infection and Immunity

SN - 0019-9567

IS - 2

ER -