Efficacy of killed virus vaccine, live attenuated chimeric virus vaccine, and passive immunization for prevention of West Nile virus encephalitis in hamster model

Robert B. Tesh, Juan Arroyo, Amelia P A Travassos da Rosa, Hilda Guzman, Shu Yuan Xiao, Thomas P. Monath

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

Results of experiments evaluating the efficacy of three immunization strategies for the prevention of West Nile virus (WNV) encephalitis are reported. Immunization strategies evaluated included a killed virus veterinary vaccine, a live attenuated chimeric virus vaccine candidate, and passive immunization with WNV-immune serum; all were tested by using a hamster model of the disease. Each product protected the animals from clinical illness and death when challenged with a hamster-virulent wild-type WNV strain 1 month after initial immunization. The live attenuated chimeric virus vaccine candidate induced the highest humoral antibody responses, as measured by hemagglutination inhibition, complement fixation, and plaque reduction neutralization tests. Although the duration of protective immunity was not determined in this study, our preliminary results and the cumulative experience of other virus vaccines suggest that the live attenuated chimeric.

Original languageEnglish (US)
Pages (from-to)1392-1397
Number of pages6
JournalEmerging Infectious Diseases
Volume8
Issue number12
StatePublished - Dec 1 2002

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West Nile virus
Attenuated Vaccines
Inactivated Vaccines
Passive Immunization
Encephalitis
Cricetinae
Vaccines
Viruses
Immunization
Neutralization Tests
Hemagglutination
Antibody Formation
Immune Sera
Immunity

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Efficacy of killed virus vaccine, live attenuated chimeric virus vaccine, and passive immunization for prevention of West Nile virus encephalitis in hamster model. / Tesh, Robert B.; Arroyo, Juan; Travassos da Rosa, Amelia P A; Guzman, Hilda; Xiao, Shu Yuan; Monath, Thomas P.

In: Emerging Infectious Diseases, Vol. 8, No. 12, 01.12.2002, p. 1392-1397.

Research output: Contribution to journalArticle

Tesh, Robert B. ; Arroyo, Juan ; Travassos da Rosa, Amelia P A ; Guzman, Hilda ; Xiao, Shu Yuan ; Monath, Thomas P. / Efficacy of killed virus vaccine, live attenuated chimeric virus vaccine, and passive immunization for prevention of West Nile virus encephalitis in hamster model. In: Emerging Infectious Diseases. 2002 ; Vol. 8, No. 12. pp. 1392-1397.
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