Efficacy of post-exposure treatment of yellow fever with ribavirin in a hamster model of the disease

Elena Sbrana, Shu Yuan Xiao, Hilda Guzman, Mengyi Ye, Amelia P A Travassos Da Rosa, Robert B. Tesh

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Ribavirin was evaluated as a potential treatment of yellow fever (YF) in a hamster model of the disease. Ribavirin treatment during the first five days after YF virus infection improved survival, reduced tissue damage in target organs (liver and spleen), prevented hepatocellular steatosis, and normalized alanine aminotransferase levels. The results of this study suggest that ribavirin may be effective in the early treatment of YF, and that its mechanism of action in reducing liver pathology in YF virus infection may be similar to that observed with ribavirin in the treatment of chronic hepatitis C virus infection.

Original languageEnglish (US)
Pages (from-to)306-312
Number of pages7
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume71
Issue number3
StatePublished - Sep 2004

Fingerprint

Yellow Fever
Ribavirin
Cricetinae
Virus Diseases
Yellow fever virus
Tissue Survival
Liver
Chronic Hepatitis C
Alanine Transaminase
Hepacivirus
Spleen
Pathology

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Sbrana, E., Xiao, S. Y., Guzman, H., Ye, M., Travassos Da Rosa, A. P. A., & Tesh, R. B. (2004). Efficacy of post-exposure treatment of yellow fever with ribavirin in a hamster model of the disease. American Journal of Tropical Medicine and Hygiene, 71(3), 306-312.

Efficacy of post-exposure treatment of yellow fever with ribavirin in a hamster model of the disease. / Sbrana, Elena; Xiao, Shu Yuan; Guzman, Hilda; Ye, Mengyi; Travassos Da Rosa, Amelia P A; Tesh, Robert B.

In: American Journal of Tropical Medicine and Hygiene, Vol. 71, No. 3, 09.2004, p. 306-312.

Research output: Contribution to journalArticle

Sbrana, E, Xiao, SY, Guzman, H, Ye, M, Travassos Da Rosa, APA & Tesh, RB 2004, 'Efficacy of post-exposure treatment of yellow fever with ribavirin in a hamster model of the disease', American Journal of Tropical Medicine and Hygiene, vol. 71, no. 3, pp. 306-312.
Sbrana, Elena ; Xiao, Shu Yuan ; Guzman, Hilda ; Ye, Mengyi ; Travassos Da Rosa, Amelia P A ; Tesh, Robert B. / Efficacy of post-exposure treatment of yellow fever with ribavirin in a hamster model of the disease. In: American Journal of Tropical Medicine and Hygiene. 2004 ; Vol. 71, No. 3. pp. 306-312.
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