EGFR family and Src family kinase interactions

mechanics matters?

Zhongwen Chen, Dongmyung Oh, Alok Kumar Dubey, Mingxi Yao, Beverly Yang, Jay T. Groves, Michael Sheetz

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Receptor tyrosine kinases (RTKs), such as the EGF receptor family, and adhesion molecules, such as integrins, have historically been viewed to have distinctly separable roles in the cell. In this classical view, integrins mediate mechanical interactions between the cell and its surrounding extracellular matrix while RTKs handle signaling to modulate cellular behavior. Although crosstalk between these receptor pathways has been known to exist for a long time, this has generally been attributed to effects significantly downstream from the receptors themselves. In recent years, however, EGFR family RTKs have been found to directly participate in integrin-mediated force sensing, revealing a more complex interplay among these cellular components than originally appreciated. Here we briefly review the classical understanding of EGFR family RTK signaling and then provide a broadened perspective based on recent results.

Original languageEnglish (US)
Pages (from-to)97-102
Number of pages6
JournalCurrent Opinion in Cell Biology
Volume51
DOIs
StatePublished - Apr 1 2018
Externally publishedYes

Fingerprint

src-Family Kinases
Receptor Protein-Tyrosine Kinases
Mechanics
Integrins
Epidermal Growth Factor Receptor
Cell Communication
Protein-Tyrosine Kinases

ASJC Scopus subject areas

  • Cell Biology

Cite this

EGFR family and Src family kinase interactions : mechanics matters? / Chen, Zhongwen; Oh, Dongmyung; Dubey, Alok Kumar; Yao, Mingxi; Yang, Beverly; Groves, Jay T.; Sheetz, Michael.

In: Current Opinion in Cell Biology, Vol. 51, 01.04.2018, p. 97-102.

Research output: Contribution to journalReview article

Chen, Zhongwen ; Oh, Dongmyung ; Dubey, Alok Kumar ; Yao, Mingxi ; Yang, Beverly ; Groves, Jay T. ; Sheetz, Michael. / EGFR family and Src family kinase interactions : mechanics matters?. In: Current Opinion in Cell Biology. 2018 ; Vol. 51. pp. 97-102.
@article{56fe7949a51747418d71cb139bce421c,
title = "EGFR family and Src family kinase interactions: mechanics matters?",
abstract = "Receptor tyrosine kinases (RTKs), such as the EGF receptor family, and adhesion molecules, such as integrins, have historically been viewed to have distinctly separable roles in the cell. In this classical view, integrins mediate mechanical interactions between the cell and its surrounding extracellular matrix while RTKs handle signaling to modulate cellular behavior. Although crosstalk between these receptor pathways has been known to exist for a long time, this has generally been attributed to effects significantly downstream from the receptors themselves. In recent years, however, EGFR family RTKs have been found to directly participate in integrin-mediated force sensing, revealing a more complex interplay among these cellular components than originally appreciated. Here we briefly review the classical understanding of EGFR family RTK signaling and then provide a broadened perspective based on recent results.",
author = "Zhongwen Chen and Dongmyung Oh and Dubey, {Alok Kumar} and Mingxi Yao and Beverly Yang and Groves, {Jay T.} and Michael Sheetz",
year = "2018",
month = "4",
day = "1",
doi = "10.1016/j.ceb.2017.12.003",
language = "English (US)",
volume = "51",
pages = "97--102",
journal = "Current Opinion in Cell Biology",
issn = "0955-0674",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - EGFR family and Src family kinase interactions

T2 - mechanics matters?

AU - Chen, Zhongwen

AU - Oh, Dongmyung

AU - Dubey, Alok Kumar

AU - Yao, Mingxi

AU - Yang, Beverly

AU - Groves, Jay T.

AU - Sheetz, Michael

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Receptor tyrosine kinases (RTKs), such as the EGF receptor family, and adhesion molecules, such as integrins, have historically been viewed to have distinctly separable roles in the cell. In this classical view, integrins mediate mechanical interactions between the cell and its surrounding extracellular matrix while RTKs handle signaling to modulate cellular behavior. Although crosstalk between these receptor pathways has been known to exist for a long time, this has generally been attributed to effects significantly downstream from the receptors themselves. In recent years, however, EGFR family RTKs have been found to directly participate in integrin-mediated force sensing, revealing a more complex interplay among these cellular components than originally appreciated. Here we briefly review the classical understanding of EGFR family RTK signaling and then provide a broadened perspective based on recent results.

AB - Receptor tyrosine kinases (RTKs), such as the EGF receptor family, and adhesion molecules, such as integrins, have historically been viewed to have distinctly separable roles in the cell. In this classical view, integrins mediate mechanical interactions between the cell and its surrounding extracellular matrix while RTKs handle signaling to modulate cellular behavior. Although crosstalk between these receptor pathways has been known to exist for a long time, this has generally been attributed to effects significantly downstream from the receptors themselves. In recent years, however, EGFR family RTKs have been found to directly participate in integrin-mediated force sensing, revealing a more complex interplay among these cellular components than originally appreciated. Here we briefly review the classical understanding of EGFR family RTK signaling and then provide a broadened perspective based on recent results.

UR - http://www.scopus.com/inward/record.url?scp=85039748097&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85039748097&partnerID=8YFLogxK

U2 - 10.1016/j.ceb.2017.12.003

DO - 10.1016/j.ceb.2017.12.003

M3 - Review article

VL - 51

SP - 97

EP - 102

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

SN - 0955-0674

ER -