Ehrlichia chaffeensis TRP120 activates canonical notch signaling to downregulate TLR2/4 expression and promote intracellular survival

Keyphrases

• Toll-like 100%
• Ehrlichia Chaffeensis 100%
• Intracellular Survival 100%
• Receptor 2 100%
• Notch Pathway 100%
• ADAM17 100%
• Canonical Notch Signaling 100%
• Effector Proteins 75%
• Host-pathogen Interactions 50%
• Metalloprotease 50%
• Tandem Repeat Protein 50%
• Notch Signaling 50%
• Notch1 50%
• Notch Signaling Pathway 50%
• Nuclear Translocation 25%
• Host Cell 25%
• Age of Infection 25%
• Intracellular Pathogen 25%
• Recombinant 25%
• Etiological Agents 25%
• Novel Mechanism 25%
• Life-threatening 25%
• Pharmacological Inhibitors 25%
• Intracellular Bacteria 25%
• Human Monocytic Ehrlichiosis 25%
• Small Interfering RNA (siRNA) 25%
• Host Innate Immune Response 25%
• P38 Mitogen-activated Protein Kinase (p38 MAPK) 25%
• Mononuclear Phagocytes 25%
• Pathway Activation 25%
• Small Genome 25%
• Intracellular Infection 25%
• Gene Expression Level 25%
• Evolutionarily Conserved 25%
• Evade 25%
• Molecular Strategies 25%
• Secretase 25%
• Downstream Effects 25%
• Extracellular Signal-regulated Kinase 1/2 25%
• PU.1 25%
• Transcriptionally Active 25%
• Innate Immune Defense 25%
• Transcription Factor Complex 25%
• Innate Host Defense 25%
• Cell Reprogramming 25%
• Signaling Genes 25%
• Tick-borne Zoonosis 25%
• Notch Receptors 25%
• Notch Intracellular Domain 25%
• Reprogramming Strategies 25%

Biochemistry, Genetics and Molecular Biology

• Ehrlichia Chaffeensis 100%
• Notch 100%
• Notch Signaling Pathway 100%
• TLR2 100%
• ADAM17 42%
• Tandem Repeat 28%
• Host Pathogen Interaction 28%
• Metalloproteinase 28%
• Metalloendopeptidase 28%
• Transcription Factors 14%
• Infectious Agent 14%
• Upregulation 14%
• Enzyme 14%
• Innate Immunity 14%
• Host Resistance 14%
• Intracellular Bacterium 14%
• Mononuclear Phagocyte 14%
• Extracellular Signal-Regulated Kinases 14%
• Secretase 14%
• Gene Expression Level 14%
• Notch Proteins 14%
• Nuclear Reprogramming 14%
• P38 Mitogen-Activated Protein Kinases 14%
• Small Interfering RNA 14%

Immunology and Microbiology

• Ehrlichia Chaffeensis 100%
• TLR2 100%
• Notch 100%
• Notch Signaling 100%
• ADAM17 37%
• Infection 37%
• Host-Pathogen Interaction 25%
• Tandem Repeat 25%
• Protein Repeat 25%
• Mitogen 12%
• Innate Immune System 12%
• Host Cell 12%
• Infectious Agent 12%
• Upregulation 12%
• Host Resistance 12%
• Intracellular Bacterium 12%
• Transcription Factors 12%
• Zoonosis 12%
• Mononuclear Phagocyte 12%
• Gene Expression Level 12%
• Nuclear Reprogramming 12%
• Ribonucleic Acid 12%