Ehrlichia chaffeensis TRP120-mediated ubiquitination and proteasomal degradation of tumor suppressor FBW7 increases oncoprotein stability and promotes infection

Keyphrases

• Bortezomib 7%
• C-Jun 14%
• C-Myc 14%
• Catalytic Site 7%
• Cell Apoptosis 7%
• Cell Signaling Pathways 7%
• Cell Survival 7%
• Co-immunoprecipitation (co-IP) 14%
• Cullin1 7%
• Cyclin E 7%
• E3 Ubiquitin Ligase 7%
• Ectopic Expression 14%
• Ehrlichia Chaffeensis 100%
• Evolutionarily Conserved 7%
• FBW7 100%
• Gene Expression 7%
• HECT E3 Ligase 21%
• Host Defense 7%
• Host Signals 7%
• Immunofluorescence Microscopy 7%
• Infected Cells 7%
• Innate Immune Response 7%
• K48 Ubiquitination 7%
• Knockdown 7%
• Ligase 7%
• Myeloid Cell leukemia-1 (Mcl-1) 14%
• Negatively Regulate 7%
• Notch Intracellular Domain 7%
• Oncoprotein 100%
• Post-infection 7%
• Protease Inhibitors 7%
• Proteasomal Degradation 100%
• Recombinant 7%
• SKP1 7%
• Substrate Recognition 7%
• Tumor Suppressor 100%
• Ubiquitin Ligase Activity 7%
• Ubiquitin-mediated Degradation 100%
• Ubiquitination 7%
• WD Domain 7%
• WD40 Domain 7%

Biochemistry, Genetics and Molecular Biology

• Cell Survival 20%
• Cullin 20%
• Cyclin E 20%
• Ectopic Expression 40%
• Ehrlichia Chaffeensis 100%
• Gene Expression 20%
• Host Resistance 20%
• Immunoprecipitation 20%
• Ligase 20%
• MCL1 20%
• Notch 80%
• SCF Complex 20%
• Signal Transduction 40%
• Skp1 20%
• Tumor Suppressor Protein 100%
• Ubiquitin Ligase 20%
• Ubiquitin-Conjugating Enzyme 60%
• Ubiquitination 100%
• WD40 Repeat 40%

Immunology and Microbiology

• Cell Survival 20%
• Cyclin E 20%
• Ectopic Expression 40%
• Ehrlichia Chaffeensis 100%
• Gene Expression 20%
• Host Cell 20%
• Host Resistance 20%
• Immunoprecipitation 20%
• Notch 80%
• Signal Transduction 40%
• Ubiquitination 100%
• WD Repeat 40%