Ehrlichia moonlighting effectors and interkingdom interactions with the mononuclear phagocyte

Paige Selvy Dunphy, Tian Luo, Jere McBride

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Ehrlichia chaffeensis is an obligately intracellular gram negative bacterium with a small genome that thrives in mammalian mononuclear phagocytes by exploiting eukaryotic processes. Herein, we discuss the latest findings on moonlighting tandem repeat protein effectors and their secretion mechanisms, and novel molecular interkingdom interactions that provide insight into the intracellular pathobiology of ehrlichiae.

Original languageEnglish (US)
Pages (from-to)1005-1016
Number of pages12
JournalMicrobes and Infection
Volume15
Issue number14-15
DOIs
StatePublished - Dec 2013

Fingerprint

Ehrlichia chaffeensis
Ehrlichia
Tandem Repeat Sequences
Phagocytes
Gram-Negative Bacteria
Genome
Proteins

Keywords

  • Effector
  • Ehrlichia
  • Human monocytotropic ehrlichiosis
  • Moonlighting protein
  • Nucleomodulin
  • Post translational modification
  • Tandem repeat protein
  • Type 1 secretion system
  • Zoonosis

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

Ehrlichia moonlighting effectors and interkingdom interactions with the mononuclear phagocyte. / Dunphy, Paige Selvy; Luo, Tian; McBride, Jere.

In: Microbes and Infection, Vol. 15, No. 14-15, 12.2013, p. 1005-1016.

Research output: Contribution to journalArticle

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