Ehrlichia moonlighting effectors and interkingdom interactions with the mononuclear phagocyte

Paige Selvy Dunphy, Tian Luo, Jere W. McBride

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Ehrlichia chaffeensis is an obligately intracellular gram negative bacterium with a small genome that thrives in mammalian mononuclear phagocytes by exploiting eukaryotic processes. Herein, we discuss the latest findings on moonlighting tandem repeat protein effectors and their secretion mechanisms, and novel molecular interkingdom interactions that provide insight into the intracellular pathobiology of ehrlichiae.

Original languageEnglish (US)
Pages (from-to)1005-1016
Number of pages12
JournalMicrobes and Infection
Volume15
Issue number14-15
DOIs
StatePublished - Dec 1 2013

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Keywords

  • Effector
  • Ehrlichia
  • Human monocytotropic ehrlichiosis
  • Moonlighting protein
  • Nucleomodulin
  • Post translational modification
  • Tandem repeat protein
  • Type 1 secretion system
  • Zoonosis

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases

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