Ehrlichia moonlighting effectors and interkingdom interactions with the mononuclear phagocyte

Paige Selvy Dunphy; Tian Luo; Jere W. McBride

doi:10.1016/j.micinf.2013.09.011

Ehrlichia moonlighting effectors and interkingdom interactions with the mononuclear phagocyte

Paige Selvy Dunphy
, Tian Luo
, Jere W. McBride

Pathology

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Ehrlichia chaffeensis is an obligately intracellular gram negative bacterium with a small genome that thrives in mammalian mononuclear phagocytes by exploiting eukaryotic processes. Herein, we discuss the latest findings on moonlighting tandem repeat protein effectors and their secretion mechanisms, and novel molecular interkingdom interactions that provide insight into the intracellular pathobiology of ehrlichiae.

Original language	English (US)
Pages (from-to)	1005-1016
Number of pages	12
Journal	Microbes and Infection
Volume	15
Issue number	14-15
DOIs	https://doi.org/10.1016/j.micinf.2013.09.011
State	Published - Dec 2013

Keywords

Effector
Ehrlichia
Human monocytotropic ehrlichiosis
Moonlighting protein
Nucleomodulin
Post translational modification
Tandem repeat protein
Type 1 secretion system
Zoonosis

ASJC Scopus subject areas

Microbiology
Immunology
Infectious Diseases

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10.1016/j.micinf.2013.09.011

Cite this

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title = "Ehrlichia moonlighting effectors and interkingdom interactions with the mononuclear phagocyte",

abstract = "Ehrlichia chaffeensis is an obligately intracellular gram negative bacterium with a small genome that thrives in mammalian mononuclear phagocytes by exploiting eukaryotic processes. Herein, we discuss the latest findings on moonlighting tandem repeat protein effectors and their secretion mechanisms, and novel molecular interkingdom interactions that provide insight into the intracellular pathobiology of ehrlichiae.",

keywords = "Effector, Ehrlichia, Human monocytotropic ehrlichiosis, Moonlighting protein, Nucleomodulin, Post translational modification, Tandem repeat protein, Type 1 secretion system, Zoonosis",

author = "Dunphy, \{Paige Selvy\} and Tian Luo and McBride, \{Jere W.\}",

note = "Funding Information: We thank all current and former laboratory members for discussions and scientific contributions towards understanding the pathobiology of Ehrlichia infections. This work was supported by grant AI105536 from the National Institute of Allergy and Infectious Diseases (NIAID) and jointly by the Clayton Foundation for Research . PSD was supported by NIH Emerging Infectious Diseases and Biodefense Training grant T32 AI007536 .",

year = "2013",

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doi = "10.1016/j.micinf.2013.09.011",

language = "English (US)",

volume = "15",

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journal = "Microbes and Infection",

issn = "1286-4579",

publisher = "Elsevier Masson",

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TY - JOUR

T1 - Ehrlichia moonlighting effectors and interkingdom interactions with the mononuclear phagocyte

AU - Dunphy, Paige Selvy

AU - Luo, Tian

AU - McBride, Jere W.

N1 - Funding Information: We thank all current and former laboratory members for discussions and scientific contributions towards understanding the pathobiology of Ehrlichia infections. This work was supported by grant AI105536 from the National Institute of Allergy and Infectious Diseases (NIAID) and jointly by the Clayton Foundation for Research . PSD was supported by NIH Emerging Infectious Diseases and Biodefense Training grant T32 AI007536 .

PY - 2013/12

Y1 - 2013/12

N2 - Ehrlichia chaffeensis is an obligately intracellular gram negative bacterium with a small genome that thrives in mammalian mononuclear phagocytes by exploiting eukaryotic processes. Herein, we discuss the latest findings on moonlighting tandem repeat protein effectors and their secretion mechanisms, and novel molecular interkingdom interactions that provide insight into the intracellular pathobiology of ehrlichiae.

AB - Ehrlichia chaffeensis is an obligately intracellular gram negative bacterium with a small genome that thrives in mammalian mononuclear phagocytes by exploiting eukaryotic processes. Herein, we discuss the latest findings on moonlighting tandem repeat protein effectors and their secretion mechanisms, and novel molecular interkingdom interactions that provide insight into the intracellular pathobiology of ehrlichiae.

KW - Effector

KW - Ehrlichia

KW - Human monocytotropic ehrlichiosis

KW - Moonlighting protein

KW - Nucleomodulin

KW - Post translational modification

KW - Tandem repeat protein

KW - Type 1 secretion system

KW - Zoonosis

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UR - https://www.scopus.com/pages/publications/84889079800#tab=citedBy

U2 - 10.1016/j.micinf.2013.09.011

DO - 10.1016/j.micinf.2013.09.011

M3 - Article

C2 - 24141087

AN - SCOPUS:84889079800

SN - 1286-4579

VL - 15

SP - 1005

EP - 1016

JO - Microbes and Infection

JF - Microbes and Infection

IS - 14-15

ER -

Ehrlichia moonlighting effectors and interkingdom interactions with the mononuclear phagocyte

Abstract

Keywords

ASJC Scopus subject areas

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