Electrical stimulation of small intestinal electrical control activity

S. K. Sarna, E. E. Daniel

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The small intestinal electrical control activity (ECA) was driven by an electrical stimulus and the resultant effects on the frequency and the phase relationships of control waves recorded. The small intestinal ECA can be driven from all sites from which it could be recorded. The mean maximum driven frequency (MDF) was the highest near the pylorus and it decreased distally, but at any given site it was the same before and after dividing the small intestine into small segments. The length of the frequency plateau decreased and phase lag per cm increased with an increase in plateau frequency. The direction of phase lag was orad proximal to a stimulation site and aborad distal to it. Intravenous atropine (up to 100 μg per kg) or reserpinization of dogs before an experiment had no effect on the MDF in the frequency plateau region. The study confirms the validity of an array of bidirectionally coupled relaxation oscillators as a model of small intestinal ECA and shows that the frequency and the phase relationship of small intestinal control waves can be altered by electrical stimulation. The study also points out some differences between the small intestinal and gastric ECA's at the cellular level.

Original languageEnglish
Pages (from-to)660-667
Number of pages8
JournalGastroenterology
Volume69
Issue number3
StatePublished - 1975
Externally publishedYes

Fingerprint

Pylorus
Atropine
Electric Stimulation
Small Intestine
Stomach
Dogs
Direction compound

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Sarna, S. K., & Daniel, E. E. (1975). Electrical stimulation of small intestinal electrical control activity. Gastroenterology, 69(3), 660-667.

Electrical stimulation of small intestinal electrical control activity. / Sarna, S. K.; Daniel, E. E.

In: Gastroenterology, Vol. 69, No. 3, 1975, p. 660-667.

Research output: Contribution to journalArticle

Sarna, SK & Daniel, EE 1975, 'Electrical stimulation of small intestinal electrical control activity', Gastroenterology, vol. 69, no. 3, pp. 660-667.
Sarna, S. K. ; Daniel, E. E. / Electrical stimulation of small intestinal electrical control activity. In: Gastroenterology. 1975 ; Vol. 69, No. 3. pp. 660-667.
@article{80903f5e5d34490ca14a260597d5a528,
title = "Electrical stimulation of small intestinal electrical control activity",
abstract = "The small intestinal electrical control activity (ECA) was driven by an electrical stimulus and the resultant effects on the frequency and the phase relationships of control waves recorded. The small intestinal ECA can be driven from all sites from which it could be recorded. The mean maximum driven frequency (MDF) was the highest near the pylorus and it decreased distally, but at any given site it was the same before and after dividing the small intestine into small segments. The length of the frequency plateau decreased and phase lag per cm increased with an increase in plateau frequency. The direction of phase lag was orad proximal to a stimulation site and aborad distal to it. Intravenous atropine (up to 100 μg per kg) or reserpinization of dogs before an experiment had no effect on the MDF in the frequency plateau region. The study confirms the validity of an array of bidirectionally coupled relaxation oscillators as a model of small intestinal ECA and shows that the frequency and the phase relationship of small intestinal control waves can be altered by electrical stimulation. The study also points out some differences between the small intestinal and gastric ECA's at the cellular level.",
author = "Sarna, {S. K.} and Daniel, {E. E.}",
year = "1975",
language = "English",
volume = "69",
pages = "660--667",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "3",

}

TY - JOUR

T1 - Electrical stimulation of small intestinal electrical control activity

AU - Sarna, S. K.

AU - Daniel, E. E.

PY - 1975

Y1 - 1975

N2 - The small intestinal electrical control activity (ECA) was driven by an electrical stimulus and the resultant effects on the frequency and the phase relationships of control waves recorded. The small intestinal ECA can be driven from all sites from which it could be recorded. The mean maximum driven frequency (MDF) was the highest near the pylorus and it decreased distally, but at any given site it was the same before and after dividing the small intestine into small segments. The length of the frequency plateau decreased and phase lag per cm increased with an increase in plateau frequency. The direction of phase lag was orad proximal to a stimulation site and aborad distal to it. Intravenous atropine (up to 100 μg per kg) or reserpinization of dogs before an experiment had no effect on the MDF in the frequency plateau region. The study confirms the validity of an array of bidirectionally coupled relaxation oscillators as a model of small intestinal ECA and shows that the frequency and the phase relationship of small intestinal control waves can be altered by electrical stimulation. The study also points out some differences between the small intestinal and gastric ECA's at the cellular level.

AB - The small intestinal electrical control activity (ECA) was driven by an electrical stimulus and the resultant effects on the frequency and the phase relationships of control waves recorded. The small intestinal ECA can be driven from all sites from which it could be recorded. The mean maximum driven frequency (MDF) was the highest near the pylorus and it decreased distally, but at any given site it was the same before and after dividing the small intestine into small segments. The length of the frequency plateau decreased and phase lag per cm increased with an increase in plateau frequency. The direction of phase lag was orad proximal to a stimulation site and aborad distal to it. Intravenous atropine (up to 100 μg per kg) or reserpinization of dogs before an experiment had no effect on the MDF in the frequency plateau region. The study confirms the validity of an array of bidirectionally coupled relaxation oscillators as a model of small intestinal ECA and shows that the frequency and the phase relationship of small intestinal control waves can be altered by electrical stimulation. The study also points out some differences between the small intestinal and gastric ECA's at the cellular level.

UR - http://www.scopus.com/inward/record.url?scp=0016766996&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016766996&partnerID=8YFLogxK

M3 - Article

VL - 69

SP - 660

EP - 667

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 3

ER -