Electro-acupuncture relieves chronic visceral hyperalgesia in rats

K. M. Cui, W. M. Li, X. Gao, K. Chung, Jin Chung, G. C. Wu

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Acupuncture treatment is one of the most desirable choices for the management of pain including chronic visceral pain, but its scientific evidence and laws of action are not very clear at this point. In this study, we examined the immediate and cumulative effects of electro-acupuncture (EA) on chronic visceral pain induced by colorectal distention (CRD) stimuli in rats using an irritable bowel syndrome (IBS) model (a chronic visceral hypersensitivity model). The results demonstrated that EA could significantly depress both abnormally increased abdominal withdrawal reflex (AWR) scores and the magnitude of electromyograms (EMGs) recorded from the rectus abdominis in response to CRD stimulation at strengths of 20, 40, 60, and 80 mmHg. Repeated EA treatment for 14 days showed that the effects of EA on both abnormal AWRs and EMGs appeared 2-4 days after the start of the EA application session, gradually enhanced to its maximum within 8-12 days, and lasted 5 days after EA treatment stopped. These data provide evidence that visceral pain associated with the rat IBS model can be effectively treated by EA and opens up the possibility of clinical treatment of chronic visceral pain with acupuncture.

Original languageEnglish (US)
Pages (from-to)20-23
Number of pages4
JournalNeuroscience Letters
Volume376
Issue number1
DOIs
StatePublished - Mar 7 2005

Fingerprint

Hyperalgesia
Acupuncture
Visceral Pain
Acupuncture Therapy
Chronic Pain
Irritable Bowel Syndrome
Electromyography
Abdominal Reflex
Rectus Abdominis
Pain Management
Hypersensitivity

Keywords

  • Abdominal withdrawal reflex
  • Chronic visceral hyperalgesia
  • Colorectal distention stimulation
  • Electro-acupuncture
  • Irritable bowel syndrome
  • Rectus abdominis muscle

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Electro-acupuncture relieves chronic visceral hyperalgesia in rats. / Cui, K. M.; Li, W. M.; Gao, X.; Chung, K.; Chung, Jin; Wu, G. C.

In: Neuroscience Letters, Vol. 376, No. 1, 07.03.2005, p. 20-23.

Research output: Contribution to journalArticle

Cui, K. M. ; Li, W. M. ; Gao, X. ; Chung, K. ; Chung, Jin ; Wu, G. C. / Electro-acupuncture relieves chronic visceral hyperalgesia in rats. In: Neuroscience Letters. 2005 ; Vol. 376, No. 1. pp. 20-23.
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