Electroacupuncture ameliorates experimental colitis induced by acetic acid in rat.

Jeoung Woo Kang, Tae Wan Kim, Jun Ho La, Tae Sik Sung, Hyun Ju Kim, Young Bae Kwon, Jeum Yong Kim, Il Suk Yang

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10 Scopus citations

Abstract

The effect of electroacupuncture (EA) on experimental colitis was investigated in Sprague-Dawley rats. Colitis was induced by intracolonic instillation of 4% acetic acid. EA (2 Hz, 0.05 ms, 2 V for 20 min) was applied to bilateral Hoku (LI-4) and Zusanli (ST-36) on 12 hrs and 36 hrs after induction of colitis. EA-treatment significantly reduced the macroscopic damage and the myeloperoxidase activity of colonic samples at 3 days post-induction of colitis. Colitic colon showed a decreased in vitro motility. However, colonic motility of EA-treated group was not significantly different from that of normal group. The anti-inflammatory effect of EA was not inhibited by a glucocorticoid receptor antagonist, RU-486, but suppressed by a beta-adrenoceptor antagonist, propranonol. These results suggest that EA-treatment has a beneficial effect on colitis, and its anti-inflammatory effect is mediated by beta-adrenoceptor activation but not by endogenous glucocorticoiddependent mechanism.

Original languageEnglish (US)
Pages (from-to)189-195
Number of pages7
JournalJournal of veterinary science (Suwon-si, Korea)
Volume5
Issue number3
DOIs
StatePublished - Sep 2004

ASJC Scopus subject areas

  • veterinary(all)

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