Electroacupuncture ameliorates experimental colitis induced by acetic acid in rat.

Jeoung Woo Kang, Tae Wan Kim, Jun-Ho La, Tae Sik Sung, Hyun Ju Kim, Young Bae Kwon, Jeum Yong Kim, Il Suk Yang

Research output: Contribution to journalArticle

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Abstract

The effect of electroacupuncture (EA) on experimental colitis was investigated in Sprague-Dawley rats. Colitis was induced by intracolonic instillation of 4% acetic acid. EA (2 Hz, 0.05 ms, 2 V for 20 min) was applied to bilateral Hoku (LI-4) and Zusanli (ST-36) on 12 hrs and 36 hrs after induction of colitis. EA-treatment significantly reduced the macroscopic damage and the myeloperoxidase activity of colonic samples at 3 days post-induction of colitis. Colitic colon showed a decreased in vitro motility. However, colonic motility of EA-treated group was not significantly different from that of normal group. The anti-inflammatory effect of EA was not inhibited by a glucocorticoid receptor antagonist, RU-486, but suppressed by a beta-adrenoceptor antagonist, propranonol. These results suggest that EA-treatment has a beneficial effect on colitis, and its anti-inflammatory effect is mediated by beta-adrenoceptor activation but not by endogenous glucocorticoiddependent mechanism.

Original languageEnglish (US)
Pages (from-to)189-195
Number of pages7
JournalJournal of Veterinary Science
Volume5
Issue number3
StatePublished - Sep 2004
Externally publishedYes

Fingerprint

Electroacupuncture
colitis
Colitis
Acetic Acid
acetic acid
rats
anti-inflammatory activity
antagonists
Adrenergic Receptors
Anti-Inflammatory Agents
myeloperoxidase
Mifepristone
Glucocorticoid Receptors
colon
Peroxidase
Sprague Dawley Rats
Colon
Therapeutics

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Kang, J. W., Kim, T. W., La, J-H., Sung, T. S., Kim, H. J., Kwon, Y. B., ... Yang, I. S. (2004). Electroacupuncture ameliorates experimental colitis induced by acetic acid in rat. Journal of Veterinary Science, 5(3), 189-195.

Electroacupuncture ameliorates experimental colitis induced by acetic acid in rat. / Kang, Jeoung Woo; Kim, Tae Wan; La, Jun-Ho; Sung, Tae Sik; Kim, Hyun Ju; Kwon, Young Bae; Kim, Jeum Yong; Yang, Il Suk.

In: Journal of Veterinary Science, Vol. 5, No. 3, 09.2004, p. 189-195.

Research output: Contribution to journalArticle

Kang, JW, Kim, TW, La, J-H, Sung, TS, Kim, HJ, Kwon, YB, Kim, JY & Yang, IS 2004, 'Electroacupuncture ameliorates experimental colitis induced by acetic acid in rat.', Journal of Veterinary Science, vol. 5, no. 3, pp. 189-195.
Kang, Jeoung Woo ; Kim, Tae Wan ; La, Jun-Ho ; Sung, Tae Sik ; Kim, Hyun Ju ; Kwon, Young Bae ; Kim, Jeum Yong ; Yang, Il Suk. / Electroacupuncture ameliorates experimental colitis induced by acetic acid in rat. In: Journal of Veterinary Science. 2004 ; Vol. 5, No. 3. pp. 189-195.
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