Electroantennograms (EAGs) and electroretinograms (ERGs) in the genetic dissection of synaptic function in Drosophila melanogaster

Balaji Krishnan, Yogesh Wairkar

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Electroantennograms (EAGs) and electroretinograms (ERGs) are extracuticular recording techniques that require stimulations from two distinct sensory stimuli and have been instrumental in mapping the role of seven transmembrane receptors and downstream signaling in the transduction of the sensory stimulus to synaptic signals. This review will provide an overview of the different approaches used with these two techniques and the underlying success seen in the implementation of vertebrate studies that led to translational outcomes. We will review systematically the classic approach and its modifications and emphasize how electrophysiological studies of visual and olfactory transduction provided insights that have been instrumental in discovering signaling mechanisms that are disrupted in diverse neurological states including neurodegeneration and circadian rhythms.

Original languageEnglish (US)
Title of host publicationNeuromethods
PublisherHumana Press Inc.
Number of pages28
StatePublished - Jan 1 2018

Publication series

ISSN (Print)0893-2336
ISSN (Electronic)1940-6045


  • Drosophila
  • Electroantennogram
  • Electroretinogram
  • Extracuticular
  • Neurodegeneration
  • Neurogenetics
  • Olfaction
  • Sensory reception
  • Vision

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Psychiatry and Mental health


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