ELECTRON MICROSCOPICAL AND IMMUNOLOGICAL OBSERVATIONS ON THE SERUM-HEPATITIS (S.H.) ANTIGEN IN PRIMARY BILIARY CIRRHOSIS

Kai Krohn, P. T. Jokelainen, N. D C Finlayson, Karl Anderson, A. M. Prince

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Particles identical to those associated with S.H. antigen were found by electron microscopy in the sera of 11 out of 12 patients with primary biliary cirrhosis. Antigen and/or antibody to S.H. antigen or antiserum were found in 9 out of 10 cases by immunological methods. It is suggested that immune complexes involving an antigen similar to or identical with S.H. antigen may be present in primary biliary cirrhosis, and that it may be important in the pathogenesis of the disease.

Original languageEnglish (US)
Pages (from-to)379-383
Number of pages5
JournalThe Lancet
Volume296
Issue number7669
DOIs
StatePublished - Aug 22 1970
Externally publishedYes

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Hepatitis Antigens
Biliary Liver Cirrhosis
Electrons
Hepatitis B e Antigens
Serum
Antigens
Antigen-Antibody Complex
Immune Sera
Electron Microscopy
Antibodies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

ELECTRON MICROSCOPICAL AND IMMUNOLOGICAL OBSERVATIONS ON THE SERUM-HEPATITIS (S.H.) ANTIGEN IN PRIMARY BILIARY CIRRHOSIS. / Krohn, Kai; Jokelainen, P. T.; Finlayson, N. D C; Anderson, Karl; Prince, A. M.

In: The Lancet, Vol. 296, No. 7669, 22.08.1970, p. 379-383.

Research output: Contribution to journalArticle

Krohn, Kai ; Jokelainen, P. T. ; Finlayson, N. D C ; Anderson, Karl ; Prince, A. M. / ELECTRON MICROSCOPICAL AND IMMUNOLOGICAL OBSERVATIONS ON THE SERUM-HEPATITIS (S.H.) ANTIGEN IN PRIMARY BILIARY CIRRHOSIS. In: The Lancet. 1970 ; Vol. 296, No. 7669. pp. 379-383.
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