Particles identical to those associated with S.H. antigen were found by electron microscopy in the sera of 11 out of 12 patients with primary biliary cirrhosis. Antigen and/or antibody to S.H. antigen or antiserum were found in 9 out of 10 cases by immunological methods. It is suggested that immune complexes involving an antigen similar to or identical with S.H. antigen may be present in primary biliary cirrhosis, and that it may be important in the pathogenesis of the disease.
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