Electrospray ionization fourier transform ion cyclotron resonance mass spectrometry

Christopher L. Hendrickson, Mark Emmett

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

The basic principles and recent advances in electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry are reviewed. A brief history of electrospray ionization is provided, along with a complete technical description of the technique, electrospray ionization variations, and advantages. Next, the fundamental principles of Fourier transform ion cyclotron resonance mass spectrometry are covered, including ion cyclotron motion, ion cyclotron resonance excitation, and image current detection. Instrumentation and methods used to couple these techniques are then described. Topics include ion source configuration, ion transport through a strong magnetic field gradient, and ion trapping methods. The article concludes with selected applications that highlight the strengths of electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry.

Original languageEnglish (US)
Pages (from-to)517-536
Number of pages20
JournalAnnual Review of Physical Chemistry
Volume50
StatePublished - 1999
Externally publishedYes

Fingerprint

Cyclotron resonance
Electrospray ionization
cyclotron resonance
Mass spectrometry
Fourier transforms
mass spectroscopy
Ions
ionization
ions
ion motion
Cyclotrons
ion sources
Ion sources
cyclotrons
trapping
histories
gradients
Magnetic fields
configurations
magnetic fields

Keywords

  • ESI
  • FT MS
  • FT-ICR
  • ICR

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry

Cite this

Electrospray ionization fourier transform ion cyclotron resonance mass spectrometry. / Hendrickson, Christopher L.; Emmett, Mark.

In: Annual Review of Physical Chemistry, Vol. 50, 1999, p. 517-536.

Research output: Contribution to journalArticle

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