Electrospray ionization fourier transform ion cyclotron resonance mass spectrometry

Christopher L. Hendrickson, Mark R. Emmett

Research output: Contribution to journalArticle

76 Scopus citations

Abstract

The basic principles and recent advances in electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry are reviewed. A brief history of electrospray ionization is provided, along with a complete technical description of the technique, electrospray ionization variations, and advantages. Next, the fundamental principles of Fourier transform ion cyclotron resonance mass spectrometry are covered, including ion cyclotron motion, ion cyclotron resonance excitation, and image current detection. Instrumentation and methods used to couple these techniques are then described. Topics include ion source configuration, ion transport through a strong magnetic field gradient, and ion trapping methods. The article concludes with selected applications that highlight the strengths of electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry.

Original languageEnglish (US)
Pages (from-to)517-536
Number of pages20
JournalAnnual Review of Physical Chemistry
Volume50
DOIs
StatePublished - Jan 1 1999
Externally publishedYes

Keywords

  • ESI
  • FT MS
  • FT-ICR
  • ICR

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry

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