Elevated chemokine levels during adult but not pediatric crimean-congo hemorrhagic fever

Mehmet Arasli, Yasemin Ozsurekci, Nazif Elaldi, Alexander J. McAuley, Eda Karadag Oncel, Ishak Ozel Tekin, Mustafa Gokhan Gozel, Ali Kaya, Fusun Dilara Icagasioglu, Dilek Yagci Caglayik, Gulay Korukluoglu, Furuzan Kokturk, Mehmet Bakir, Dennis A. Bente, Mehmet Ceyhan

Research output: Contribution to journalArticle

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Abstract

Background: Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral zoonosis. Clinical reports indicate the severity of CCHF is milder in children than adults. The chemokines are important chemo-attractant mediators of the host immune system. Objectives: The main aim of the study was to identify whether or not there were any differences in chemokine levels between the pediatric and adult patients and control groups, and whether there was any correlation with disease severity. Study design: The serum levels of select chemokines including chemokine (C-C) ligand 2 (CCL2), CCL3, CCL4, chemokine (C-X-C) ligand 8 (CXCL8), CXCL9, and granulocyte-colony stimulating factor (G-CSF) in 29 adult and 32 pediatric CCHF patients and in 35 healthy children and 40 healthy adult control groups were studied by flow cytometric bead immunoassay method. Results: Great variability was detected in the serum levels of the chemokines for both the adult and pediatric patients and controls. With the exception of G-CSF, the median serum levels of CCL2, CCL3, CCL4, CXCL8, and CXCL9 were found to be significantly higher in the adult patients compared to adult controls (2364.7 vs. 761. pg/ml; 714.1 vs. 75.2. pg/ml; 88.6 vs. 25.5. pg/ml; 217.9 vs. 18.3. pg/ml; 875 vs. 352.2. pg/ml, respectively, p<. 0.0001 for all comparisons). Among the chemokines the median CCL4 and G-CSF levels were significantly higher in the pediatric patients compared to pediatric controls (40.3 vs. 7.1. pg/ml, p<. 0.0001; 0.1 vs. 0.1. pg/ml, p= 0.049, respectively). Conclusion: The results of this study showed prominent chemokine raising in adult CCHF patients compared to children CCHF patients.

Original languageEnglish
Pages (from-to)76-82
Number of pages7
JournalJournal of Clinical Virology
Volume66
DOIs
StatePublished - May 1 2015

Fingerprint

Crimean Hemorrhagic Fever
Congo
Chemokines
Pediatrics
Granulocyte Colony-Stimulating Factor
Ligands
Serum
Chemokine CCL4
CXC Chemokines
Control Groups
Zoonoses
Ticks
Immunoassay
Immune System

Keywords

  • Adults
  • Chemokine
  • Children
  • Crimean-Congo hemorrhagic fever

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Arasli, M., Ozsurekci, Y., Elaldi, N., McAuley, A. J., Oncel, E. K., Tekin, I. O., ... Ceyhan, M. (2015). Elevated chemokine levels during adult but not pediatric crimean-congo hemorrhagic fever. Journal of Clinical Virology, 66, 76-82. https://doi.org/10.1016/j.jcv.2015.03.010

Elevated chemokine levels during adult but not pediatric crimean-congo hemorrhagic fever. / Arasli, Mehmet; Ozsurekci, Yasemin; Elaldi, Nazif; McAuley, Alexander J.; Oncel, Eda Karadag; Tekin, Ishak Ozel; Gozel, Mustafa Gokhan; Kaya, Ali; Icagasioglu, Fusun Dilara; Caglayik, Dilek Yagci; Korukluoglu, Gulay; Kokturk, Furuzan; Bakir, Mehmet; Bente, Dennis A.; Ceyhan, Mehmet.

In: Journal of Clinical Virology, Vol. 66, 01.05.2015, p. 76-82.

Research output: Contribution to journalArticle

Arasli, M, Ozsurekci, Y, Elaldi, N, McAuley, AJ, Oncel, EK, Tekin, IO, Gozel, MG, Kaya, A, Icagasioglu, FD, Caglayik, DY, Korukluoglu, G, Kokturk, F, Bakir, M, Bente, DA & Ceyhan, M 2015, 'Elevated chemokine levels during adult but not pediatric crimean-congo hemorrhagic fever', Journal of Clinical Virology, vol. 66, pp. 76-82. https://doi.org/10.1016/j.jcv.2015.03.010
Arasli, Mehmet ; Ozsurekci, Yasemin ; Elaldi, Nazif ; McAuley, Alexander J. ; Oncel, Eda Karadag ; Tekin, Ishak Ozel ; Gozel, Mustafa Gokhan ; Kaya, Ali ; Icagasioglu, Fusun Dilara ; Caglayik, Dilek Yagci ; Korukluoglu, Gulay ; Kokturk, Furuzan ; Bakir, Mehmet ; Bente, Dennis A. ; Ceyhan, Mehmet. / Elevated chemokine levels during adult but not pediatric crimean-congo hemorrhagic fever. In: Journal of Clinical Virology. 2015 ; Vol. 66. pp. 76-82.
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abstract = "Background: Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral zoonosis. Clinical reports indicate the severity of CCHF is milder in children than adults. The chemokines are important chemo-attractant mediators of the host immune system. Objectives: The main aim of the study was to identify whether or not there were any differences in chemokine levels between the pediatric and adult patients and control groups, and whether there was any correlation with disease severity. Study design: The serum levels of select chemokines including chemokine (C-C) ligand 2 (CCL2), CCL3, CCL4, chemokine (C-X-C) ligand 8 (CXCL8), CXCL9, and granulocyte-colony stimulating factor (G-CSF) in 29 adult and 32 pediatric CCHF patients and in 35 healthy children and 40 healthy adult control groups were studied by flow cytometric bead immunoassay method. Results: Great variability was detected in the serum levels of the chemokines for both the adult and pediatric patients and controls. With the exception of G-CSF, the median serum levels of CCL2, CCL3, CCL4, CXCL8, and CXCL9 were found to be significantly higher in the adult patients compared to adult controls (2364.7 vs. 761. pg/ml; 714.1 vs. 75.2. pg/ml; 88.6 vs. 25.5. pg/ml; 217.9 vs. 18.3. pg/ml; 875 vs. 352.2. pg/ml, respectively, p<. 0.0001 for all comparisons). Among the chemokines the median CCL4 and G-CSF levels were significantly higher in the pediatric patients compared to pediatric controls (40.3 vs. 7.1. pg/ml, p<. 0.0001; 0.1 vs. 0.1. pg/ml, p= 0.049, respectively). Conclusion: The results of this study showed prominent chemokine raising in adult CCHF patients compared to children CCHF patients.",
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AU - Arasli, Mehmet

AU - Ozsurekci, Yasemin

AU - Elaldi, Nazif

AU - McAuley, Alexander J.

AU - Oncel, Eda Karadag

AU - Tekin, Ishak Ozel

AU - Gozel, Mustafa Gokhan

AU - Kaya, Ali

AU - Icagasioglu, Fusun Dilara

AU - Caglayik, Dilek Yagci

AU - Korukluoglu, Gulay

AU - Kokturk, Furuzan

AU - Bakir, Mehmet

AU - Bente, Dennis A.

AU - Ceyhan, Mehmet

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N2 - Background: Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral zoonosis. Clinical reports indicate the severity of CCHF is milder in children than adults. The chemokines are important chemo-attractant mediators of the host immune system. Objectives: The main aim of the study was to identify whether or not there were any differences in chemokine levels between the pediatric and adult patients and control groups, and whether there was any correlation with disease severity. Study design: The serum levels of select chemokines including chemokine (C-C) ligand 2 (CCL2), CCL3, CCL4, chemokine (C-X-C) ligand 8 (CXCL8), CXCL9, and granulocyte-colony stimulating factor (G-CSF) in 29 adult and 32 pediatric CCHF patients and in 35 healthy children and 40 healthy adult control groups were studied by flow cytometric bead immunoassay method. Results: Great variability was detected in the serum levels of the chemokines for both the adult and pediatric patients and controls. With the exception of G-CSF, the median serum levels of CCL2, CCL3, CCL4, CXCL8, and CXCL9 were found to be significantly higher in the adult patients compared to adult controls (2364.7 vs. 761. pg/ml; 714.1 vs. 75.2. pg/ml; 88.6 vs. 25.5. pg/ml; 217.9 vs. 18.3. pg/ml; 875 vs. 352.2. pg/ml, respectively, p<. 0.0001 for all comparisons). Among the chemokines the median CCL4 and G-CSF levels were significantly higher in the pediatric patients compared to pediatric controls (40.3 vs. 7.1. pg/ml, p<. 0.0001; 0.1 vs. 0.1. pg/ml, p= 0.049, respectively). Conclusion: The results of this study showed prominent chemokine raising in adult CCHF patients compared to children CCHF patients.

AB - Background: Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral zoonosis. Clinical reports indicate the severity of CCHF is milder in children than adults. The chemokines are important chemo-attractant mediators of the host immune system. Objectives: The main aim of the study was to identify whether or not there were any differences in chemokine levels between the pediatric and adult patients and control groups, and whether there was any correlation with disease severity. Study design: The serum levels of select chemokines including chemokine (C-C) ligand 2 (CCL2), CCL3, CCL4, chemokine (C-X-C) ligand 8 (CXCL8), CXCL9, and granulocyte-colony stimulating factor (G-CSF) in 29 adult and 32 pediatric CCHF patients and in 35 healthy children and 40 healthy adult control groups were studied by flow cytometric bead immunoassay method. Results: Great variability was detected in the serum levels of the chemokines for both the adult and pediatric patients and controls. With the exception of G-CSF, the median serum levels of CCL2, CCL3, CCL4, CXCL8, and CXCL9 were found to be significantly higher in the adult patients compared to adult controls (2364.7 vs. 761. pg/ml; 714.1 vs. 75.2. pg/ml; 88.6 vs. 25.5. pg/ml; 217.9 vs. 18.3. pg/ml; 875 vs. 352.2. pg/ml, respectively, p<. 0.0001 for all comparisons). Among the chemokines the median CCL4 and G-CSF levels were significantly higher in the pediatric patients compared to pediatric controls (40.3 vs. 7.1. pg/ml, p<. 0.0001; 0.1 vs. 0.1. pg/ml, p= 0.049, respectively). Conclusion: The results of this study showed prominent chemokine raising in adult CCHF patients compared to children CCHF patients.

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