Elevated maternal glucose concentrations and placental infection in twin pregnancies

Barbara Luke, Morton B. Brown, Ruta B. Misiunas, Jill G. Mauldin, Roger B. Newman, Clark Nugent, Victor H. Gonzalez-Quintero, Frank R. Witter, Gary Hankins, Mary D'Alton, George A. Macones, David A. Grainger

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

OBJECTIVE: To evaluate the association between maternal screening glucose concentration and placental infection in nondiabetic twin pregnancies. STUDY DESIGN: One thousand sixty-one nondiabetic twin pregnancies at ≥ 28 weeks' gestation were divided into 3 groups based on the screening 50-g fasting glucose concentration at 24-28 weeks: lowest quartile (< 96 mg/dL), middle 2 quartiles (96-128 mg/dL) and upper quartile (> 128 mg/dL). Outcomes were modeled using general linear and multinomial logistic regression, controlling for confounding factors. RESULTS: The middle and highest glucose groups were associated with increased risks for clinical chorioamnionitis (adjusted OR [AOR] 3.18, 95% CI 1.34, 7.54; AOR 6.80, CI 1.89, 24.53, respectively). Birth at < 32 weeks and histologic diagnosis of placental infection (chorioamnionitis, funisitis, necrosis, vasculitis or villitis) were significantly associated only with the highest glucose group (AOR 1.79, CI 1.02, 3.13; AOR 6.95, CI 1.10, 8.68, respectively). CONCLUSION: Elevated screening glucose in nondiabetic twin pregnancies may be a marker of placental inflammation and infection.

Original languageEnglish (US)
Pages (from-to)241-245
Number of pages5
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume50
Issue number4
StatePublished - Apr 2005
Externally publishedYes

Fingerprint

Twin Pregnancy
Chorioamnionitis
Mothers
Glucose
Infection
Vasculitis
Fasting
Necrosis
Logistic Models
Parturition
Inflammation
Pregnancy

Keywords

  • Blood glucose
  • Placental diseases
  • Pregnancy complications
  • Twins

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Luke, B., Brown, M. B., Misiunas, R. B., Mauldin, J. G., Newman, R. B., Nugent, C., ... Grainger, D. A. (2005). Elevated maternal glucose concentrations and placental infection in twin pregnancies. Journal of Reproductive Medicine for the Obstetrician and Gynecologist, 50(4), 241-245.

Elevated maternal glucose concentrations and placental infection in twin pregnancies. / Luke, Barbara; Brown, Morton B.; Misiunas, Ruta B.; Mauldin, Jill G.; Newman, Roger B.; Nugent, Clark; Gonzalez-Quintero, Victor H.; Witter, Frank R.; Hankins, Gary; D'Alton, Mary; Macones, George A.; Grainger, David A.

In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist, Vol. 50, No. 4, 04.2005, p. 241-245.

Research output: Contribution to journalArticle

Luke, B, Brown, MB, Misiunas, RB, Mauldin, JG, Newman, RB, Nugent, C, Gonzalez-Quintero, VH, Witter, FR, Hankins, G, D'Alton, M, Macones, GA & Grainger, DA 2005, 'Elevated maternal glucose concentrations and placental infection in twin pregnancies', Journal of Reproductive Medicine for the Obstetrician and Gynecologist, vol. 50, no. 4, pp. 241-245.
Luke, Barbara ; Brown, Morton B. ; Misiunas, Ruta B. ; Mauldin, Jill G. ; Newman, Roger B. ; Nugent, Clark ; Gonzalez-Quintero, Victor H. ; Witter, Frank R. ; Hankins, Gary ; D'Alton, Mary ; Macones, George A. ; Grainger, David A. / Elevated maternal glucose concentrations and placental infection in twin pregnancies. In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist. 2005 ; Vol. 50, No. 4. pp. 241-245.
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