Elevated maternal glucose concentrations and placental infection in twin pregnancies

Barbara Luke, Morton B. Brown, Ruta B. Misiunas, Jill G. Mauldin, Roger B. Newman, Clark Nugent, Victor H. Gonzalez-Quintero, Frank R. Witter, Gary D.V. Hankins, Mary D'Alton, George A. Macones, David A. Grainger

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


OBJECTIVE: To evaluate the association between maternal screening glucose concentration and placental infection in nondiabetic twin pregnancies. STUDY DESIGN: One thousand sixty-one nondiabetic twin pregnancies at ≥ 28 weeks' gestation were divided into 3 groups based on the screening 50-g fasting glucose concentration at 24-28 weeks: lowest quartile (< 96 mg/dL), middle 2 quartiles (96-128 mg/dL) and upper quartile (> 128 mg/dL). Outcomes were modeled using general linear and multinomial logistic regression, controlling for confounding factors. RESULTS: The middle and highest glucose groups were associated with increased risks for clinical chorioamnionitis (adjusted OR [AOR] 3.18, 95% CI 1.34, 7.54; AOR 6.80, CI 1.89, 24.53, respectively). Birth at < 32 weeks and histologic diagnosis of placental infection (chorioamnionitis, funisitis, necrosis, vasculitis or villitis) were significantly associated only with the highest glucose group (AOR 1.79, CI 1.02, 3.13; AOR 6.95, CI 1.10, 8.68, respectively). CONCLUSION: Elevated screening glucose in nondiabetic twin pregnancies may be a marker of placental inflammation and infection.

Original languageEnglish (US)
Pages (from-to)241-245
Number of pages5
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Issue number4
StatePublished - Apr 2005
Externally publishedYes


  • Blood glucose
  • Placental diseases
  • Pregnancy complications
  • Twins

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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