Elevated phospholipase D isoform 1 in Alzheimer's disease patients’ hippocampus: Relevance to synaptic dysfunction and memory deficits

Keyphrases

• Memory Deficits 100%
• Phospholipase D 100%
• Hippocampus 100%
• Alzheimer's Disease Patient 100%
• Synaptic Memory 100%
• Synaptic Dysfunction 100%
• Phospholipase D1 (PLD1) 100%
• Alzheimer's Disease 27%
• Alzheimer's Disease Model 27%
• 3xTg-AD 27%
• Wild Mice 18%
• Long-term Potentiation 18%
• Age-matched 18%
• Temporal Cortex 18%
• Human Studies 9%
• Aging 9%
• Pharmacological Approaches 9%
• Overexpression 9%
• Mouse Model 9%
• Therapeutic Intervention 9%
• Clinical Trials 9%
• Signaling Mechanism 9%
• Therapeutic Targeting 9%
• Oligomeric 9%
• Phospholipase D Activity 9%
• Western Blot Analysis 9%
• Transgenic Mouse Model 9%
• Specific Expression 9%
• Neuropathology 9%
• Age-dependent 9%
• Disease-related 9%
• Frontal Cortex 9%
• Complementary Approach 9%
• Brain Aging 9%
• Synaptosomes 9%
• Slowing down 9%
• Future Therapeutics 9%
• Microtubule-associated Protein tau 9%
• Phosphatidylcholine 9%
• High-frequency Stimulation 9%
• Mouse Hippocampus 9%
• Novel Object Recognition 9%
• Postmortem Tissue 9%
• Oligomeric tau 9%
• Hippocampal Long-term Potentiation 9%
• Human Amyloid Precursor Protein 9%
• Isoform-specific 9%
• Membrane Phospholipids 9%
• Seven-transmembrane Receptor 9%
• Slice Preparation 9%
• Presenilin 1 mutation 9%
• Lipolytic Enzymes 9%
• Human Hippocampus 9%
• Novel Object Recognition Memory 9%
• Phospholipase D2 (PLD2) 9%

Biochemistry, Genetics and Molecular Biology

• Isoform 100%
• Phospholipase D 100%
• Long Term Potentiation 75%
• Mouse Model 50%
• Wild Type Mouse 50%
• Preclinical Study 50%
• Human Study 25%
• Enzyme 25%
• Signaling Mechanism 25%
• Transgenic Mouse 25%
• Clinical Trial 25%
• Amyloid Precursor Protein 25%
• Tau 25%
• Tau Protein 25%
• Transmembrane Receptors 25%
• Slice Preparation 25%
• Presenilin 25%
• PLD2 25%
• Western Blotting 25%
• Amyloid Protein 25%
• Phospholipid 25%
• Lecithin 25%

Neuroscience

• Alzheimer's Disease 100%
• Amnesia 100%
• Phospholipase D 100%
• Hippocampus 100%
• Long-Term Potentiation 30%
• Temporal Lobe 20%
• Amyloid Precursor Protein 10%
• Signaling Mechanism 10%
• Frontal Lobe 10%
• Synaptosome 10%
• Oligomer 10%
• Tau Protein 10%
• Amyloid Protein 10%
• Presenilin 1 10%
• Recognition Memory 10%
• Membrane Phospholipid 10%
• Lecithin 10%
• Brain Age 10%
• Transmembrane Receptors 10%
• Western Blotting 10%