Elevated plasma high-sensitivity C-reactive protein concentrations in Asian Indians living in the United States

Manisha Chandalia, Alberto V. Cabo-Chan, Sridevi Devaraj, Ishwarlal Jialal, Scott M. Grundy, Nicola Abate

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Proinflammatory state may contribute to the excessive prevalence of type 2 diabetes and cardiovascular disease observed in populations originating from the Indian subcontinent (Asian Indians). This study was conducted to evaluate whether nondiabetic Asian Indian men living in the United States manifest a proinflammatory state when compared with Caucasians of similar age and body fat content. We also compared the relationships between plasma high-sensitivity C-reactive protein (hs-CRP), a marker of low-grade inflammation, and various parameters of body composition and fat distribution and insulin sensitivity in Asian Indians and Caucasians. For this purpose, plasma hs-CRP, oral glucose tolerance test, and anthropometric measurements were conducted in 82 Asian Indian men and 55 Caucasian men of similar age. The two groups had similar body fat content and truncal skin-folds thickness. Asian Indians had higher insulin areas under the curve during oral glucose tolerance tests, indicating a greater insulin resistance. Asian Indians also manifested a significant elevation of plasma hs-CRP. We conclude that young, overtly healthy Asian Indian men have both greater insulin resistance and higher hs-CRP levels than do Caucasians. This difference cannot be explained by greater adiposity in Asian Indians and suggests that many Asian Indians have an underlying proinflammatory state that may contribute to their increased risk for both type 2 diabetes and cardiovascular disease.

Original languageEnglish
Pages (from-to)3773-3776
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume88
Issue number8
DOIs
StatePublished - Aug 1 2003
Externally publishedYes

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C-Reactive Protein
Insulin
Plasmas
Fats
Medical problems
Insulin Resistance
Glucose
Glucose Tolerance Test
Type 2 Diabetes Mellitus
Adipose Tissue
Cardiovascular Diseases
Skin
Body Fat Distribution
Adiposity
Body Composition
Area Under Curve
Chemical analysis
Inflammation
Population

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Elevated plasma high-sensitivity C-reactive protein concentrations in Asian Indians living in the United States. / Chandalia, Manisha; Cabo-Chan, Alberto V.; Devaraj, Sridevi; Jialal, Ishwarlal; Grundy, Scott M.; Abate, Nicola.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 88, No. 8, 01.08.2003, p. 3773-3776.

Research output: Contribution to journalArticle

Chandalia, Manisha ; Cabo-Chan, Alberto V. ; Devaraj, Sridevi ; Jialal, Ishwarlal ; Grundy, Scott M. ; Abate, Nicola. / Elevated plasma high-sensitivity C-reactive protein concentrations in Asian Indians living in the United States. In: Journal of Clinical Endocrinology and Metabolism. 2003 ; Vol. 88, No. 8. pp. 3773-3776.
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