TY - JOUR
T1 - Elevated postoperative blood glucose and preoperative hemoglobin a1c are associated with increased wound complications following total joint arthroplasty
AU - Stryker, Louis S.
AU - Abdel, Matthew P.
AU - Morrey, Mark E.
AU - Morrow, Melissa M.
AU - Kor, Daryl J.
AU - Morrey, Bernard F.
PY - 2013/5/1
Y1 - 2013/5/1
N2 - Background: Diabetes is an established risk factor for complications following total joint arthroplasty. However, the correlation between postoperative blood glucose and preoperative hemoglobin A1C levels with complications following total joint arthroplasty is not well described. Methods: All patients undergoing elective primary total joint arthroplasty at our institution from 2004 through 2011 with both postoperative blood glucose and preoperative hemoglobin A1C levels were identified in a retrospective review. From among 1702 patients, those with wound complications within thirty days after the index arthroplasty were identified. A control group matched for exact age, sex, procedure, tourniquet use, surgical approach, and use of antibiotic cement was also created. Thirty patients met the study group inclusion criteria. The mean patient age was seventy-two years (range, fifty-three to eighty-nine years); the majority (53%) of patients were female. Results: The odds ratio for developing a wound complication was 3.75 (95% confidence interval, 1.25 to 11.22; p =0.02) in patients with a mean postoperative glucose of >200 mg/dL, 3.0 (95% confidence interval, 0.97 to 9.30; p = 0.08) in patients with a maximum postoperative blood glucose of >260 mg/dL, and 9.0 (95% confidence interval, 1.14 to 71.20; p = 0.03) in patients with a preoperative hemoglobin A1C value of >6.7%. Conclusions: Patients with a mean postoperative blood glucose of >200 mg/dL or a preoperative hemoglobin A1C level of >6.7% are at increased risk for wound complications following elective primary total joint arthroplasty. These results show that poor preoperative and postoperative glucose control is independently associated with wound complications. Level of Evidence: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence. COPYRIGHT
AB - Background: Diabetes is an established risk factor for complications following total joint arthroplasty. However, the correlation between postoperative blood glucose and preoperative hemoglobin A1C levels with complications following total joint arthroplasty is not well described. Methods: All patients undergoing elective primary total joint arthroplasty at our institution from 2004 through 2011 with both postoperative blood glucose and preoperative hemoglobin A1C levels were identified in a retrospective review. From among 1702 patients, those with wound complications within thirty days after the index arthroplasty were identified. A control group matched for exact age, sex, procedure, tourniquet use, surgical approach, and use of antibiotic cement was also created. Thirty patients met the study group inclusion criteria. The mean patient age was seventy-two years (range, fifty-three to eighty-nine years); the majority (53%) of patients were female. Results: The odds ratio for developing a wound complication was 3.75 (95% confidence interval, 1.25 to 11.22; p =0.02) in patients with a mean postoperative glucose of >200 mg/dL, 3.0 (95% confidence interval, 0.97 to 9.30; p = 0.08) in patients with a maximum postoperative blood glucose of >260 mg/dL, and 9.0 (95% confidence interval, 1.14 to 71.20; p = 0.03) in patients with a preoperative hemoglobin A1C value of >6.7%. Conclusions: Patients with a mean postoperative blood glucose of >200 mg/dL or a preoperative hemoglobin A1C level of >6.7% are at increased risk for wound complications following elective primary total joint arthroplasty. These results show that poor preoperative and postoperative glucose control is independently associated with wound complications. Level of Evidence: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence. COPYRIGHT
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U2 - 10.2106/JBJS.L.00494
DO - 10.2106/JBJS.L.00494
M3 - Article
C2 - 23636187
AN - SCOPUS:84879301747
SN - 0021-9355
VL - 95
SP - 808
EP - 814
JO - Journal of Bone and Joint Surgery
JF - Journal of Bone and Joint Surgery
IS - 9
ER -