Elevated total peripheral leukocyte count may identify risk for neurological disability in asphyxiated term neonates

A. A. Morkos, A. O. Hopper, D. D. Deming, S. M. Yellon, N. Wycliffe, S. Ashwal, Lawrence Sowers, R. L. Peverini, D. M. Angeles

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective: The present study investigated the relationship between neurologic outcome and total circulating white blood cell (WBC) and absolute neutrophil counts (ANCs) in the first week of life in term infants with hypoxic-ischemic encephalopathy (HIE). Study design: Long-term neurologic outcome at 18 months was measured retrospectively in 30 term neonates with HIE using the Pediatric Cerebral Performance Category Scale (PCPCS) score with outcomes dichotomized as either good or poor. We then compared white blood cell and ANC levels during the first 4 days of life and magnetic resonance imaging (MRI) obtained within the first month life between the two PCPCS groups. MRI was quantified using a validated scoring system. Results: Neonates with good long-term outcomes had significantly lower MRI scores (indicating lesser injury) than neonates with poor outcomes. More importantly, neonates with poor outcomes had significantly higher WBC and ANC levels as early as12 h after birth and up to 96 h after birth compared to those with good outcomes. These data suggest that elevated peripheral neutrophil counts in the first 96 h of life may signal or predict adverse long-term outcome. Conclusions: Our findings suggest that elevated peripheral neutrophil counts in the first 96 h of life in term infants with HIE may contribute to abnormal neurodevelopmental outcome.

Original languageEnglish (US)
Pages (from-to)365-370
Number of pages6
JournalJournal of Perinatology
Volume27
Issue number6
DOIs
StatePublished - Jun 2007
Externally publishedYes

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Leukocyte Count
Neutrophils
Brain Hypoxia-Ischemia
Newborn Infant
Leukocytes
Magnetic Resonance Imaging
Nervous System
Parturition
Pediatrics
Wounds and Injuries

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

Cite this

Morkos, A. A., Hopper, A. O., Deming, D. D., Yellon, S. M., Wycliffe, N., Ashwal, S., ... Angeles, D. M. (2007). Elevated total peripheral leukocyte count may identify risk for neurological disability in asphyxiated term neonates. Journal of Perinatology, 27(6), 365-370. https://doi.org/10.1038/sj.jp.7211750

Elevated total peripheral leukocyte count may identify risk for neurological disability in asphyxiated term neonates. / Morkos, A. A.; Hopper, A. O.; Deming, D. D.; Yellon, S. M.; Wycliffe, N.; Ashwal, S.; Sowers, Lawrence; Peverini, R. L.; Angeles, D. M.

In: Journal of Perinatology, Vol. 27, No. 6, 06.2007, p. 365-370.

Research output: Contribution to journalArticle

Morkos, AA, Hopper, AO, Deming, DD, Yellon, SM, Wycliffe, N, Ashwal, S, Sowers, L, Peverini, RL & Angeles, DM 2007, 'Elevated total peripheral leukocyte count may identify risk for neurological disability in asphyxiated term neonates', Journal of Perinatology, vol. 27, no. 6, pp. 365-370. https://doi.org/10.1038/sj.jp.7211750
Morkos, A. A. ; Hopper, A. O. ; Deming, D. D. ; Yellon, S. M. ; Wycliffe, N. ; Ashwal, S. ; Sowers, Lawrence ; Peverini, R. L. ; Angeles, D. M. / Elevated total peripheral leukocyte count may identify risk for neurological disability in asphyxiated term neonates. In: Journal of Perinatology. 2007 ; Vol. 27, No. 6. pp. 365-370.
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