Embryology and pathophysiology of the Chiari i and II malformations

Mohammadali Mohajel Shoja, R. Shane Tubbs, W. Jerry Oakes

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Hindbrain herniation is only one component of the Chiari malformations. These malformations often have other associated intracranial anomalies and malformations of the vertebral column. Depending on embryologic timing, -herniation of the cerebellar vermis or tonsils occurs. Additionally, the herniated hindbrain may include the medulla oblongata and fourth ventricle. Currently, no single theory explains all of the malformations seen in the Chiari I and II malformations. These pathologic derailments seem to result from a heterogeneous spectrum of ontogenetic errors and pathological mechanisms, which share some common phenotypical presentations. In this chapter, the theories pertinent to the embryology and pathophysiology of Chiari I and II malformations and their associated anomalies are discussed.

Original languageEnglish (US)
Title of host publicationThe Chiari Malformations
PublisherSpringer New York
Pages55-72
Number of pages18
Volume9781461463696
ISBN (Electronic)9781461463696
ISBN (Print)1461463688, 9781461463689
DOIs
StatePublished - Mar 1 2013
Externally publishedYes

Keywords

  • Arnold-Chiari
  • Cerebellum
  • Hindbrain herniation
  • Posterior cranial fossa
  • Tonsillar ectopia

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Embryology and pathophysiology of the Chiari i and II malformations'. Together they form a unique fingerprint.

Cite this