Embryology and pathophysiology of the Chiari i and II malformations

Mohammadali Mohajel Shoja, R. Shane Tubbs, W. Jerry Oakes

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

Hindbrain herniation is only one component of the Chiari malformations. These malformations often have other associated intracranial anomalies and malformations of the vertebral column. Depending on embryologic timing, -herniation of the cerebellar vermis or tonsils occurs. Additionally, the herniated hindbrain may include the medulla oblongata and fourth ventricle. Currently, no single theory explains all of the malformations seen in the Chiari I and II malformations. These pathologic derailments seem to result from a heterogeneous spectrum of ontogenetic errors and pathological mechanisms, which share some common phenotypical presentations. In this chapter, the theories pertinent to the embryology and pathophysiology of Chiari I and II malformations and their associated anomalies are discussed.

Original languageEnglish (US)
Title of host publicationThe Chiari Malformations
PublisherSpringer New York
Pages55-72
Number of pages18
Volume9781461463696
ISBN (Electronic)9781461463696
ISBN (Print)1461463688, 9781461463689
DOIs
StatePublished - Mar 1 2013
Externally publishedYes

Fingerprint

Rhombencephalon
Embryology
Fourth Ventricle
Medulla Oblongata
Palatine Tonsil
Spine
Cerebellar Vermis

Keywords

  • Arnold-Chiari
  • Cerebellum
  • Hindbrain herniation
  • Posterior cranial fossa
  • Tonsillar ectopia

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Mohajel Shoja, M., Tubbs, R. S., & Oakes, W. J. (2013). Embryology and pathophysiology of the Chiari i and II malformations. In The Chiari Malformations (Vol. 9781461463696, pp. 55-72). Springer New York. https://doi.org/10.1007/978-1-4614-6369-6_4

Embryology and pathophysiology of the Chiari i and II malformations. / Mohajel Shoja, Mohammadali; Tubbs, R. Shane; Oakes, W. Jerry.

The Chiari Malformations. Vol. 9781461463696 Springer New York, 2013. p. 55-72.

Research output: Chapter in Book/Report/Conference proceedingChapter

Mohajel Shoja, M, Tubbs, RS & Oakes, WJ 2013, Embryology and pathophysiology of the Chiari i and II malformations. in The Chiari Malformations. vol. 9781461463696, Springer New York, pp. 55-72. https://doi.org/10.1007/978-1-4614-6369-6_4
Mohajel Shoja M, Tubbs RS, Oakes WJ. Embryology and pathophysiology of the Chiari i and II malformations. In The Chiari Malformations. Vol. 9781461463696. Springer New York. 2013. p. 55-72 https://doi.org/10.1007/978-1-4614-6369-6_4
Mohajel Shoja, Mohammadali ; Tubbs, R. Shane ; Oakes, W. Jerry. / Embryology and pathophysiology of the Chiari i and II malformations. The Chiari Malformations. Vol. 9781461463696 Springer New York, 2013. pp. 55-72
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