@article{c2df3755797e41789585997958e4a0a3,
title = "Embryonic Ectoderm Development (EED) as a Novel Target for Cancer Treatment",
abstract = "The polycomb repressive complex 2 (PRC2) can methylate at lysine 27 of histone H3 at the trimethylation level (H3K27me3). This leads to gene silencing and is known to be dysregulated in many cancers. PRC2 is made up of three core subunits: EZH2, SUZ12, and EED. EED is essential for the regulation of PRC2 function by binding to H3K27me3. Targeting the allosteric site within EED offers new strategies to disrupt the PRC2 activity. In this minireview, we summarize some of the recent developments in small molecules that target EED and its interaction with other core proteins in the PRC2 complex.",
keywords = "Cancer, Degrader, EED, EZH2, Inhibitor, PRC2",
author = "Nicholas Cook and Jianping Chen and Jia Zhou and Daqing Wu",
note = "Funding Information: This work was supported by the National Cancer Institute grants 1R41CA206725-01A1, 1R41CA217491 and 2R42CA217491-02A1, Georgia Research Alliance Venture-Lab Award, Emory University Winship Cancer Institute Prostate Cancer Research Pilot Grant, and the Department of Education Title III Program at Clark Atlanta University (D. Wu). J. Zhou was partially supported by the John D. Funding Information: This work was supported by the National Cancer Institute grants 1R41CA206725-01A1, 1R41CA217491 and 2R42CA217491-02A1, Georgia Research Alliance VentureLab Award, Emory University Winship Cancer Institute Prostate Cancer Research Pilot Grant, and the Department of Education Title III Program at Clark Atlanta University (D. Wu). J. Zhou was partially supported by the John D. Stobo, M.D. Distinguished Chair Endowment Fund at the University of Texas Medical Branch (UTMB). Publisher Copyright: {\textcopyright} 2021 Bentham Science Publishers.",
year = "2021",
month = dec,
doi = "10.2174/1568026621666210920154942",
language = "English (US)",
volume = "21",
pages = "2771--2777",
journal = "Current Topics in Medicinal Chemistry",
issn = "1568-0266",
publisher = "Bentham Science Publishers B.V.",
number = "31",
}