Embryonic expression of glial cell-line derived neurotrophic factor (GDNF) suggests multiple developmental roles in neural differentiation and epithelial-mesenchymal interactions

Helen L. Hellmich; Lidia Kos; Edward S. Cho; Kathleen A. Mahon; Andreas Zimmer

doi:10.1016/0925-4773(95)00464-5

Embryonic expression of glial cell-line derived neurotrophic factor (GDNF) suggests multiple developmental roles in neural differentiation and epithelial-mesenchymal interactions

Helen L. Hellmich, Lidia Kos, Edward S. Cho, Kathleen A. Mahon, Andreas Zimmer

Research output: Contribution to journal › Article › peer-review

212 Scopus citations

Abstract

We describe the cloning of the mouse glial cell line-derived neurotrophic factor (GDNF) gene and its expression during embryogenesis. GDNF is a distant member of the superfamily of TGF-β related genes that was originally identified on the basis of its striking neurotrophic activity. GDNF is expressed in a highly dynamic pattern in the anterior neuroectoderm during early stages of neurogenesis between E7.5 and E10.5. Beginning at E10.5 GDNF is also expressed in several organs that develop through inductive epithelial-mesenchymal interactions. In those organs, GDNF expression is strictly confined to mesenchymal tissues and is not found in epithelia. Our results suggest multiple roles for GDNF during early stages of neuronal development and in epithelial-mesenchymal interactions.

Original language	English (US)
Pages (from-to)	95-105
Number of pages	11
Journal	Mechanisms of Development
Volume	54
Issue number	1
DOIs	https://doi.org/10.1016/0925-4773(95)00464-5
State	Published - Jan 1996
Externally published	Yes

Keywords

Central nervous system
Gene expression
Intestine development
Kidney development
Mesenchyme

ASJC Scopus subject areas

Embryology
Developmental Biology

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10.1016/0925-4773(95)00464-5

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Embryonic expression of glial cell-line derived neurotrophic factor (GDNF) suggests multiple developmental roles in neural differentiation and epithelial-mesenchymal interactions. / Hellmich, Helen L.; Kos, Lidia; Cho, Edward S. et al.
In: Mechanisms of Development, Vol. 54, No. 1, 01.1996, p. 95-105.

Research output: Contribution to journal › Article › peer-review

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AU - Zimmer, Andreas

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Embryonic expression of glial cell-line derived neurotrophic factor (GDNF) suggests multiple developmental roles in neural differentiation and epithelial-mesenchymal interactions

Abstract

Keywords

ASJC Scopus subject areas

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