Emergence and potential for spread of Chikungunya virus in Brazil

Marcio Roberto Teixeira Nunes, Nuno Rodrigues Faria, Janaina Mota de Vasconcelos, Nick Golding, Moritz U G Kraemer, Layanna Freitas de Oliveira, Raimunda do Socorro da Silva Azevedo, Daisy Elaine Andrade da Silva, Eliana Vieira Pinto da Silva, Sandro Patroca da Silva, Valéria Lima Carvalho, Giovanini Evelim Coelho, Ana Cecília Ribeiro Cruz, Sueli Guerreiro Rodrigues, Joao Lídio da Silva Gonçalves Vianez, Bruno Tardelli Diniz Nunes, Jedson Ferreira Cardoso, Robert B. Tesh, Simon I. Hay, Oliver G. PybusPedro Fernando da Costa Vasconcelos

Research output: Contribution to journalArticle

164 Citations (Scopus)

Abstract

Background: In December 2013, an outbreak of Chikungunya virus (CHIKV) caused by the Asian genotype was notified in the Caribbean. The outbreak has since spread to 38 regions in the Americas. By September 2014, the first autochthonous CHIKV infections were confirmed in Oiapoque, North Brazil, and in Feira de Santana, Northeast Brazil. Methods: We compiled epidemiological and clinical data on suspected CHIKV cases in Brazil and polymerase-chain-reaction-based diagnostic was conducted on 68 serum samples from patients with symptom onset between April and September 2014. Two imported and four autochthonous cases were selected for virus propagation, RNA isolation, full-length genome sequencing, and phylogenetic analysis. We then followed CDC/PAHO guidelines to estimate the risk of establishment of CHIKV in Brazilian municipalities. Results: We detected 41 CHIKV importations and 27 autochthonous cases in Brazil. Epidemiological and phylogenetic analyses indicated local transmission of the Asian CHIKV genotype in Oiapoque. Unexpectedly, we also discovered that the ECSA genotype is circulating in Feira de Santana. The presumed index case of the ECSA genotype was an individual who had recently returned from Angola and developed symptoms in Feira de Santana. We estimate that, if CHIKV becomes established in Brazil, transmission could occur in 94% of municipalities in the country and provide maps of the risk of importation of each strain of CHIKV in Brazil. Conclusions: The etiological strains associated with the early-phase CHIKV outbreaks in Brazil belong to the Asian and ECSA genotypes. Continued surveillance and vector mitigation strategies are needed to reduce the future public health impact of CHIKV in the Americas.

Original languageEnglish (US)
Article number102
JournalBMC Medicine
Volume13
Issue number1
DOIs
StatePublished - Apr 30 2015

Fingerprint

Chikungunya virus
Brazil
Genotype
Disease Outbreaks
Angola
Pan American Health Organization
RNA Viruses
Centers for Disease Control and Prevention (U.S.)
Public Health
Genome
Guidelines

Keywords

  • Chikungunya virus
  • National surveillance
  • Public health
  • Spatial prediction
  • Statistical methods

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Nunes, M. R. T., Faria, N. R., de Vasconcelos, J. M., Golding, N., Kraemer, M. U. G., de Oliveira, L. F., ... da Costa Vasconcelos, P. F. (2015). Emergence and potential for spread of Chikungunya virus in Brazil. BMC Medicine, 13(1), [102]. https://doi.org/10.1186/s12916-015-0348-x

Emergence and potential for spread of Chikungunya virus in Brazil. / Nunes, Marcio Roberto Teixeira; Faria, Nuno Rodrigues; de Vasconcelos, Janaina Mota; Golding, Nick; Kraemer, Moritz U G; de Oliveira, Layanna Freitas; da Silva Azevedo, Raimunda do Socorro; da Silva, Daisy Elaine Andrade; da Silva, Eliana Vieira Pinto; da Silva, Sandro Patroca; Carvalho, Valéria Lima; Coelho, Giovanini Evelim; Cruz, Ana Cecília Ribeiro; Rodrigues, Sueli Guerreiro; da Silva Gonçalves Vianez, Joao Lídio; Nunes, Bruno Tardelli Diniz; Cardoso, Jedson Ferreira; Tesh, Robert B.; Hay, Simon I.; Pybus, Oliver G.; da Costa Vasconcelos, Pedro Fernando.

In: BMC Medicine, Vol. 13, No. 1, 102, 30.04.2015.

Research output: Contribution to journalArticle

Nunes, MRT, Faria, NR, de Vasconcelos, JM, Golding, N, Kraemer, MUG, de Oliveira, LF, da Silva Azevedo, RDS, da Silva, DEA, da Silva, EVP, da Silva, SP, Carvalho, VL, Coelho, GE, Cruz, ACR, Rodrigues, SG, da Silva Gonçalves Vianez, JL, Nunes, BTD, Cardoso, JF, Tesh, RB, Hay, SI, Pybus, OG & da Costa Vasconcelos, PF 2015, 'Emergence and potential for spread of Chikungunya virus in Brazil', BMC Medicine, vol. 13, no. 1, 102. https://doi.org/10.1186/s12916-015-0348-x
Nunes MRT, Faria NR, de Vasconcelos JM, Golding N, Kraemer MUG, de Oliveira LF et al. Emergence and potential for spread of Chikungunya virus in Brazil. BMC Medicine. 2015 Apr 30;13(1). 102. https://doi.org/10.1186/s12916-015-0348-x
Nunes, Marcio Roberto Teixeira ; Faria, Nuno Rodrigues ; de Vasconcelos, Janaina Mota ; Golding, Nick ; Kraemer, Moritz U G ; de Oliveira, Layanna Freitas ; da Silva Azevedo, Raimunda do Socorro ; da Silva, Daisy Elaine Andrade ; da Silva, Eliana Vieira Pinto ; da Silva, Sandro Patroca ; Carvalho, Valéria Lima ; Coelho, Giovanini Evelim ; Cruz, Ana Cecília Ribeiro ; Rodrigues, Sueli Guerreiro ; da Silva Gonçalves Vianez, Joao Lídio ; Nunes, Bruno Tardelli Diniz ; Cardoso, Jedson Ferreira ; Tesh, Robert B. ; Hay, Simon I. ; Pybus, Oliver G. ; da Costa Vasconcelos, Pedro Fernando. / Emergence and potential for spread of Chikungunya virus in Brazil. In: BMC Medicine. 2015 ; Vol. 13, No. 1.
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AU - Nunes, Marcio Roberto Teixeira

AU - Faria, Nuno Rodrigues

AU - de Vasconcelos, Janaina Mota

AU - Golding, Nick

AU - Kraemer, Moritz U G

AU - de Oliveira, Layanna Freitas

AU - da Silva Azevedo, Raimunda do Socorro

AU - da Silva, Daisy Elaine Andrade

AU - da Silva, Eliana Vieira Pinto

AU - da Silva, Sandro Patroca

AU - Carvalho, Valéria Lima

AU - Coelho, Giovanini Evelim

AU - Cruz, Ana Cecília Ribeiro

AU - Rodrigues, Sueli Guerreiro

AU - da Silva Gonçalves Vianez, Joao Lídio

AU - Nunes, Bruno Tardelli Diniz

AU - Cardoso, Jedson Ferreira

AU - Tesh, Robert B.

AU - Hay, Simon I.

AU - Pybus, Oliver G.

AU - da Costa Vasconcelos, Pedro Fernando

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